Interactions with Lactobacillus Acidophilus

In vitro, an isolated strain of Lactobacillus acidophilus rapidly degraded sulphasalazine and phthalylsulphathiazole; the metabolic byproducts, sulphapyridine and sulphathiazole, can contribute to renal toxicity (Pradham and Majumdar 1986). More research is needed to confirm these effects in vivo.

References

Pradham A, Majumdar MK. Metabolism of some drugs by intestinal lactobacilli and their toxicological considerations. Acta Pharmacol et Toxicol. 1986;58:11-15.

This publication contains information relating to general principles of medical care that should not in any event be construed as specific instructions for individual patients. The publisher does not accept any responsibility for the accuracy of the information or the consequences arising from the application, use, or misuse of any of the information contained herein, including any injury and/or damage to any person or property as a matter of product liability, negligence, or otherwise. No warranty, expressed or implied, is made in regard to the contents of this material. No claims or endorsements are made for any drugs or compounds currently marketed or in investigative use. The reader is advised to check product information (including package inserts) for changes and new information regarding dosage, precautions, warnings, interactions, and contraindications before administering any drug, herb, or supplement discussed herein.