In vitro, quercetin (1 and 10 mM) potentiated the effects of adriamycin on
MCF-7 ADR resistant human breast cancer cells by inhibiting growth in a
dose-dependent manner (Scambia et al. 1994). Concomitant treatment with
quercetin (20 mg/kg) and cisplatin (3 mg/kg) in mice implanted with human
large-cell lung cancer reduced tumor growth to a greater degree than cisplatin
alone (Hofmann et al. 1990). More research is needed to determine if quercetin
would be a useful adjunct to chemotherapy.
Hofmann J, Fiebig HH, Winterhalter BR, Berger DP, Grunicke H. Enhancement of
the antiproliferative activity of cis-diamminedichloroplatinum (II) by
quercetin. Int J Cancer. 1990;45(3):536-539.
Scambia G, Ranelletti FO, Benedetti Panici P, et al. Quercetin potentiates
the effect of adriamycin in a multi-drug-resistant MCF-7 human breast-cancer
cell line: P-glycoprotein as a possible target. Cancer Chemother
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