Interactions with Quercetin

In vitro, quercetin (1 and 10 mM) potentiated the effects of adriamycin on MCF-7 ADR resistant human breast cancer cells by inhibiting growth in a dose-dependent manner (Scambia et al. 1994). Concomitant treatment with quercetin (20 mg/kg) and cisplatin (3 mg/kg) in mice implanted with human large-cell lung cancer reduced tumor growth to a greater degree than cisplatin alone (Hofmann et al. 1990). More research is needed to determine if quercetin would be a useful adjunct to chemotherapy.

References

Hofmann J, Fiebig HH, Winterhalter BR, Berger DP, Grunicke H. Enhancement of the antiproliferative activity of cis-diamminedichloroplatinum (II) by quercetin. Int J Cancer. 1990;45(3):536-539.

Scambia G, Ranelletti FO, Benedetti Panici P, et al. Quercetin potentiates the effect of adriamycin in a multi-drug-resistant MCF-7 human breast-cancer cell line: P-glycoprotein as a possible target. Cancer Chemother Pharmacol. 1994;34:459-464.

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