Creatine
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Central Nervous System Stimulants
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Interactions with Creatine
Central Nervous System Stimulants

There has been a report of an ischemic stroke in a male weight lifter who ingested combinations of Ma Huang (ephedra alkaloids) (40 to 60 mg/day), caffeine (400 to 600 mg/day), and creatine monohydrate (6000 mg/day) (Vahedi et al. 2000). The combination of the CNS stimulants with creatine may have contributed to the ischemic attack. Until this case, creatine alone had not been associated with cardiovascular side effects.


References

Vahedi K, Domingo V, Amarenco P, Bousser MG. Ischemic stroke in a sportsman who consumed Ma Huang extract and creatine monohydrate for body building. J Neurol Neurosurg Psychiatry. 2000;68:100-126.


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