Interactions with Turmeric

Although components of turmeric root have potently inhibited the cytochrome P450 enzyme system in rat liver (Oetari et al. 1996), specific interactions between this herb and conventional medications metabolized via the P450 system are not known to have been documented in the literature to date.

Indomethacin; Reserpine

Ethanol extracts of turmeric root (500 mg/kg) inhibited gastric secretion and protected gastroduodenal mucosa against injuries caused by drugs such as indomethacin (30 mg/kg po) and reserpine (5 mg/kg IM) in rats (Rafatullah et al. 1990).

References

Oetari S, Sudibyo M, Commandeur JN, Samhoedi R, Vermeulen NP. Effects of curcumin on cytochrome P450 and glutathione S-transferase activities in rat liver. Biochem Pharmacol. 1996;51(1):39-45.

Rafatullah S, Tariq M, Al-Yahya M, et al. Evaluation of turmeric (Curcuma longa) for gastric and duodenal antiulcer activity in rats. J Ethnopharmacol. 1990;29:25-34.

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