In vitro, rosemary extract increased the sensitivity of drug-resistant MCF-7
human breast cancer cells to doxorubicin (Plouzek et al. 1999). This interaction
may have been due to inhibition of doxorubicin binding to P-glycoprotein, which
is responsible for efflux of chemotherapeutic agents from cells. Additional
clinical studies are needed to confirm these effects in
Plouzek CA, Ciolino HP, Clarke R, Yeh GC. Inhibition of P-glycoprotein
activity and reversal of multidrug resistance in vitro by rosemary extract.
Eur J Cancer. 1999;35(10):1541-1545.
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