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Common Cold
Diabetes Mellitus
Peptic Ulcer
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Look Up > Herbs > Aloe > Interactions
Interactions with Aloe

In a single blind clinical trial of patients with diabetes mellitus, aloe vera juice (1 tbsp 80% juice bid) combined with glyburide (10 mg glibenclamide) significantly improved blood sugar levels and decreased triglyceride levels (Bunyapraphatsara et al. 1996). Glyburide alone was ineffective. The effects of the combined treatment were not greater than results obtained from treatment with aloe vera juice alone. Blood glucose levels should be monitored carefully in diabetic patients using aloe vera either alone or in combination with other antidiabetic medications in order to avoid potential hypoglycemic complications.


The topical and systemic applications of aloe vera combined with hydrocortisone 21-acetate significantly reduced edema in mice and rats with acute inflammation (Davis et al. 1991). Topically, aloe vera (5%) and hydrocortisone (0.5% aqueous solution) decreased ear inflammation in mice by 85.6%. Systemically, aloe (25 mg/kg and 100 mg/kg) combined with hydrocortisone (0.1 mg/kg and 100 mg/kg) decreased inflammation in rats by 65.7% compared to results obtained from either treatment alone; these solutions were injected on a 10 mg/kg basis to measure the inhibitory effects on paw edema.


Bunyapraphatsara N, Yongchaiyudha S, Rungpitarangsi V, et al. Antidiabetic activity of Aloe vera L. juice. II. Clinical trial in diabetes mellitus patients in combination with glibenclamide. Phytomed. 1996;3:245-248.

Davis RH, Parker WL, Murdoch DP.Aloe vera as a biologically active vehicle for hydrocortisone acetate. J Am Podiatr Med Assoc. 1991;81:1-9.

Copyright © 2000 Integrative Medicine Communications

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