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Pronunciation |
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(tet
ra hye DROZ a
leen) |
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U.S. Brand
Names |
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Collyrium Fresh® Ophthalmic [OTC];
Eyesine® Ophthalmic [OTC]; Geneye® Ophthalmic [OTC];
Mallazine® Eye Drops [OTC]; Murine® Plus Ophthalmic [OTC];
Optigene® Ophthalmic [OTC]; Tetrasine® Extra Ophthalmic [OTC];
Tetrasine® Ophthalmic [OTC]; Tyzine® Nasal; Visine®
Extra Ophthalmic
[OTC] |
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Generic
Available |
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Yes |
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Synonyms |
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Tetrahydrozoline Hydrochloride; Tetryzoline |
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Pharmacological Index |
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Adrenergic Agonist Agent; Ophthalmic Agent, Vasoconstrictor |
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Use |
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Symptomatic relief of nasal congestion and conjunctival
congestion |
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Pregnancy Risk
Factor |
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C |
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Adverse
Reactions |
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>10%:
Local: Transient stinging
Respiratory: Sneezing
1% to 10%:
Cardiovascular: Tachycardia, palpitations, hypertension, heart rate
Central nervous system: Headache
Neuromuscular & skeletal: Tremor
Ocular: Blurred vision |
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Drug
Interactions |
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Increased toxicity: MAO inhibitors can cause an exaggerated adrenergic
response if taken concurrently or within 21 days of discontinuing MAO inhibitor;
beta-blockers can cause hypertensive episodes and increased risk of intracranial
hemorrhage; anesthetics |
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Stability |
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Do not use if solution changes color or becomes cloudy |
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Mechanism of
Action |
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Stimulates alpha-adrenergic receptors in the arterioles of the conjunctiva
and the nasal mucosa to produce vasoconstriction |
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Pharmacodynamics/Kinetics |
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Onset of decongestant effect: Intranasal: Within 4-8 hours
Duration: Ophthalmic vasoconstriction: 2-3 hours |
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Usual Dosage |
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Nasal congestion: Intranasal:
Children 2-6 years: Instill 2-3 drops of 0.05% solution every 4-6 hours as
needed, no more frequent than every 3 hours
Children >6 years and Adults: Instill 2-4 drops or 3-4 sprays of 0.1%
solution every 3-4 hours as needed, no more frequent than every 3 hours
Conjunctival congestion: Ophthalmic: Adults: Instill 1-2 drops in each eye
2-4 times/day |
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Dental Health: Local
Anesthetic/Vasoconstrictor
Precautions |
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No information available to require special precautions |
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Dental Health:
Effects on Dental Treatment |
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No effects or complications reported |
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Patient
Information |
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Remove contact lenses before using in eye, do not use for more than 72 hours
unless directed to do so; consult physician if changes in vision or visual
acuity occur; do not exceed recommended dosage |
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Nursing
Implications |
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Monitor blood pressure, heart rate, symptom response |
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Dosage Forms |
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Solution, as hydrochloride:
Ophthalmic: 0.05% (15 mL) |
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