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Pronunciation |
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(proe
pee OH ma
zeen) |
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U.S. Brand
Names |
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Largon®
Injection |
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Generic
Available |
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No |
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Synonyms |
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Propiomazine Hydrochloride |
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|
Pharmacological Index |
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Antianxiety Agent, Miscellaneous; Antiemetic |
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Use |
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Relief of restlessness, nausea and apprehension before and during surgery or
during labor |
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Contraindications |
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Hypersensitivity to propiomazine |
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Adverse
Reactions |
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>10%:
Central nervous system: Dizziness, drowsiness
Gastrointestinal: Xerostomia
1% to 10%:
Cardiovascular: Tachycardia
Central nervous system: Confusion
Dermatologic: Skin rash
Gastrointestinal: Diarrhea, stomach pain
Respiratory: Shortness of breath |
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Drug
Interactions |
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CNS depressants, epinephrine |
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Usual Dosage |
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I.M., I.V.:
Adults: 10-40 mg prior to procedure, additional may be repeated at 3-hour
intervals |
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Mental Health: Effects
on Mental Status |
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Dizziness and drowsiness are common; may cause confusion; may rarely cause
neuroleptic malignant syndrome |
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Mental Health:
Effects on Psychiatric
Treatment |
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Propiomazine is a phenothiazine; concurrent use with other psychotropics may
produce additive side effects |
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Dental Health: Local
Anesthetic/Vasoconstrictor
Precautions |
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No information available to require special precautions |
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Dental Health:
Effects on Dental Treatment |
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>10% of patients experience dry mouth |
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Dosage Forms |
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Injection, as hydrochloride: 20 mg/mL (1
mL) |
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