with Evening Primrose|
In rat studies, evening primrose oil (EPO) offered protection from
cyclosporine-induced renal dysfunction (Morphake et al. 1994). Rats fed standard
chow containing 10 mL/kg EPO (representing 9% gamma-linolenic acid and 72%
cis-linolenic acid) developed fewer lesions than untreated animals following 7
days of treatment with cyclosporine (45 mg/kg/day
A double-blind cross-over study involving 13 chronic inpatients or day
patients with schizophrenia evaluated the effects of EPO (4 g) as an adjunct to
treatment (Holman and Bell 1983). No significant therapeutic effects were
associated with EPO. However, grand mal seizures occurred in two patients,
indicating that EPO may enhance the epileptogenic properties of phenothiazines.
EPO is contraindicated in patients taking phenothiazines because of the
potential for lowering the seizure threshold and increasing the risk of seizures
in this patient population (Shaw et al. 1991).
Holman CP, Bell AFJ. A trial of evening primrose oil in the treatment of
chronic schizophrenia. J Orthomol Psychiatry. 1983;12:302-304.
Morphake P, Bariety J, Darlametsos J, et al. Alteration of cyclosporine
(CsA)-induced nephrotoxicity by gamma linolenic acid (GLA) and eicosapentaenoic
acid (EPA) in Wistar rats. Prostaglandin Leukot Essent Fatty Acids.
Shaw D, Leon C, Kolev S, Murray V. Traditional remedies and food supplements;
a 5-year toxicological study (1991-1995). Drug Safety.
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