Yes

Nonsteroidal Anti-Inflammatory Agent (NSAID)

Management of inflammatory disorders, as an analgesic in the treatment of mild to moderate pain; acute gouty arthritis

D

Active GI bleeding; ulcer disease; hypersensitivity to oxyphenbutazone or any component

>10%:

Central nervous system: Dizziness

Dermatologic: Skin rash

Gastrointestinal: Abdominal cramps, heartburn, indigestion, nausea

1% to 10%:

Central nervous system: Headache, nervousness

Dermatologic: Itching

Endocrine & metabolic: Fluid retention

Gastrointestinal: Vomiting

Otic: Tinnitus

Adults: Oral:

Acute gouty arthritis: Initial: 400 mg then 100 mg every 4 hours until acute attack subsides, not longer than 1 week

Dizziness is common; may cause nervousness; may rarely cause drowsiness, confusion, depression, or hallucinations

May rarely cause agranulocytosis; use caution with clozapine and carbamazepine; may decrease lithium clearance resulting in an increase in serum lithium levels and potential lithium toxicity; monitor serum lithium levels

No information available to require special precautions

NSAID formulations are known to reversibly decrease platelet aggregation via mechanisms different than observed with aspirin. The dentist should be aware of the potential of abnormal coagulation. Caution should also be exercised in the use of NSAIDs in patients already on anticoagulant therapy with drugs such as warfarin (Coumadin®).

Take with food; may cause dizziness or drowsiness; notify physician and discontinue if persistent sore throat, fatigue, fever, or unusual bleeding or bruising occurs

Warn patients not to exceed recommended dosage; do not crush tablet

Tablet: 100 mg