No

Anorexiant

Short-term adjunct in exogenous obesity

C-IV

C

Hypersensitivity to mazindol

Tolerance may develop within a few weeks. If this occurs, discontinue drug. Do not increase dose. Not recommended for severe hypertensive patients or patients with symptomatic cardiovascular disease including arrhythmias.

Cardiovascular: Palpitation, tachycardia, edema

Central nervous system: Insomnia, overstimulation, dizziness, dysphoria, drowsiness, depression, headache, restlessness

Dermatologic: Rash, clamminess

Endocrine & metabolic: Changes in libido

Gastrointestinal: Nausea, constipation, vomiting, xerostomia, unpleasant taste, diarrhea, abdominal cramps

Genitourinary: Dysuria, polyuria, impotence

Neuromuscular & skeletal: Tremor, weakness

Ocular: Blurred vision, corneal opacities

Miscellaneous: Diaphoresis (excessive)

Symptoms of overdose include hypertension, tachycardia, and hyperthermia. Treatment is supportive.

Mazindol may decrease the hypotensive effect of guanethidine; monitor

Mazindol enhances the pressor effect of exogenous catecholamines (norepinephrine) and potential blood pressure increases in patients taking sympathomimetic medications

An isoindole with pharmacologic activity similar to amphetamine; produces CNS stimulation in humans and animals and appears to work primarily in the limbic system

Oral: Adults: Initial dose, 1 mg once daily and adjust to patient response; usual dose is 1 mg 3 times daily, 1 hour before meals, or 2 mg once daily, 1 hour before lunch; take with meals to avoid GI discomfort

No information available to require special precautions

No effects or complications reported

Take exactly as directed (do not increase dose or frequency without consulting prescriber). Take 1 hour before meals; if gastric distress occurs may be taken with meals (do not take at bedtime). Avoid alcohol, caffeine, or OTC medications that act as stimulants. You may experience restlessness, false sense of euphoria, or impaired judgment (use caution when driving or engaging in tasks requiring alertness until response to drug is known); nausea or vomiting (small frequent meals, frequent mouth care may help); constipation (increased exercise, dietary fiber, fruit, or fluid may help); diarrhea (buttermilk, boiled milk, or yogurt may help); or altered libido (reversible). Diabetics need to monitor serum glucose closely (may alter antidiabetic medication requirements). Report chest pain, palpitations, or irregular heartbeat; muscle weakness or tremors; CNS changes (aggressiveness, restlessness, euphoria, sleep disturbances); testicular pain or changes in sexual activity; blurred vision; or changes in urinary patterns. Pregnancy/breast-feeding precautions: Inform prescriber if you are or intend to be pregnant. Breast-feeding is not recommended.

Tablet:

Mazanor®: 1 mg

Sanorex®: 1 mg, 2 mg