Yes

Antitussive

Symptomatic relief of cough and symptoms of upper respiratory infection

C

Hypersensitivity to any component; patients on MAO inhibitors; patients with heart disease, hypertension, diabetes, hyperthyroidism, presence of intracranial lesion associated with increased intracranial pressure; depressed ventilatory function

May be habit-forming. Prescribe and administer with the same degree of caution appropriate to the use of other narcotic drugs or prostatic hypertrophy. Produces dose-related respiratory depression. May produce adverse reactions which may obscure the clinical course of patients with head injuries. May obscure the diagnosis or clinical course of patients with acute abdominal conditions.

Cardiovascular: Hypertension, postural hypotension, tachycardia, palpitations

Central nervous system: Sedation, drowsiness, mental clouding, lethargy, impairment of mental and physical performance, anxiety, fear, dysphoria, dizziness, psychic dependence, mood changes

Dermatologic: Rash, pruritus

Gastrointestinal: Nausea, vomiting, constipation with prolonged use

Genitourinary: Ureteral spasms, spasm of vesical sphincters and urinary retention

Ocular: Blurred vision

Respiratory: Respiratory depression

Duration: Hydrocodone: 4-6 hours

Adults: Oral: 1 tablet every 4 hours, up to 4 times/day

Use with caution since phenylephrine is a sympathomimetic amine which could interact with epinephrine to cause a pressor response

Acetaminophen: No effects or complications reported

Chlorpheniramine: Prolonged use will cause significant xerostomia

Phenylephrine: Up to 10% of patients could experience tachycardia, palpitations, and dry mouth; use vasoconstrictor with caution

Take only as prescribed; do not exceed prescribed dose or frequency. May be habit-forming. Maintain adequate hydration (2-3 L/day of fluids unless instructed to restrict fluid intake). Avoid use of other depressants, alcohol, or sleep-inducing medications, or tranquilizers or pain medications unless approved by prescriber. You may experience orthostatic hypotension (change position slowly when rising from sitting or lying or when climbing stairs); drowsiness, impaired coordination, or blurred vision (use caution when driving or engaging in tasks requiring alertness until response to drug is known); nausea or vomiting (frequent small meals, frequent mouth care, chewing gum, or sucking hard candy may help); urinary retention (void before taking medication); or constipation (increased exercise, fluids or dietary fruit and fiber may help). Report persistent CNS changes (dizziness, sedation, tremor, anxiety, mood changes, or agitation); chest pain, palpitations, rapid heartbeat; difficulty breathing; visual changes; pain on urination or inability to void; or lack of improvement or worsening or condition. Pregnancy/breast-feeding precautions: Inform prescriber if you are or intend to be pregnant. Do not breast-feed.

Tablet: Hydrocodone bitartrate 5 mg, chlorpheniramine maleate 2 mg, phenylephrine hydrochloride 10 mg, acetaminophen 250 mg, and caffeine 30 mg

Barker JD Jr, de Carle DJ, and Anuras S, "Chronic Excessive Acetaminophen Use in Liver Damage," Ann Intern Med, 1977, 87(3):299-301.

Dionne RA, Campbell RA, Cooper SA, et al, "Suppression of Postoperative Pain by Preoperative Administration of Ibuprofen in Comparison to Placebo, Acetaminophen, and Acetaminophen Plus Codeine," J Clin Pharmacol, 1983, 23(1):37-43.

Licht H, Seeff LB, and Zimmerman HJ, "Apparent Potentiation of Acetaminophen Hepatotoxicity by Alcohol," Ann Intern Med, 1980, 92(4):511.