Yes

Anticoagulant, Coumarin Derivative

Prophylaxis and treatment of thromboembolic disorders

D

Severe liver or kidney disease; open wounds; uncontrolled bleeding; hypersensitivity to dicumarol or any component

1% to 10%:

Gastrointestinal: Stomach cramps, nausea, vomiting, diarrhea

Hematologic: Leukopenia

May accentuate toxicities of oral hypoglycemics and anticonvulsants. The following will decrease prothrombin time - antacids, antihistamines, phenobarbital, carbamazepine, cholestyramine, meprobamate, glutethimide, ethchlorvynol, oral contraceptives, ranitidine, chloral hydrate, diuretics. Increased prothrombin time due to allopurinol, amiodarone, cimetidine, clofibrate, dextran, diazoxide, diflunisal, diuretics, disulfiram, fenoprofen, ibuprofen, indomethacin, influenza virus vaccine, methyldopa, methylphenidate, MAO inhibitors, naproxen, nortriptyline, phenytoin, propylthiouracil, salicylates, quinidine, quinine, ranitidine, tolbutamide, thyroid drugs, sulindac, co-trimoxazole

Interferes with hepatic synthesis of vitamin K-dependent coagulation factors (II, VII, IX, X)

Adults: Oral: 25-200 mg/day based on prothrombin time (PT) determinations

Avoid proteolytic enzymes (papain), fried/boiled onions & soybean oil

None reported

May cause leukopenia and agranulocytosis; use caution with clozapine and carbamazepine; psychotropics may increase or decrease prothrombin times; monitor prothrombin times

No information available to require special precautions

Signs of dicumarol overdose may first appear as bleeding from gingival tissue; consultation with prescribing physician is advisable prior to surgery to determine temporary dose reduction or withdrawal of medication

Tablet: 25 mg, 50 mg, 100 mg