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Pronunciation |
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(klor
fen IR a meen, fen il EF rin,
& fen il tole LOKS a meen) |
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U.S. Brand
Names |
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Comhist®; Comhist®
LA |
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Generic
Available |
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No |
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Pharmacological Index |
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Antihistamine/Decongestant Combination |
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Use |
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Symptomatic relief of rhinitis and nasal congestion due to colds or
allergy |
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Pregnancy Risk
Factor |
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C |
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Usual Dosage |
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Oral: 1 capsule every 8-12 hours or 1-2 tablets 3
times/day |
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Dental Health: Local
Anesthetic/Vasoconstrictor
Precautions |
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Use with caution since phenylephrine is a sympathomimetic amine which could
interact with epinephrine to cause a pressor response |
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Dental Health:
Effects on Dental Treatment |
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Chlorpheniramine: Prolonged use will cause significant xerostomia
Phenylephrine: Up to 10% of patients could experience tachycardia,
palpitations, and dry mouth; use vasoconstrictor with caution
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Dosage Forms |
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Capsule, sustained release (Comhist® LA):
Chlorpheniramine maleate 4 mg, phenylephrine hydrochloride 20 mg, and
phenyltoloxamine citrate 50 mg
Tablet (Comhist®): Chlorpheniramine maleate 2 mg,
phenylephrine hydrochloride 10 mg, and phenyltoloxamine citrate 25 mg
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