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Hawthorn
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Look Up > Drugs > Chlorpheniramine, Phenylephrine, and Phenyltoloxamine
Chlorpheniramine, Phenylephrine, and Phenyltoloxamine
Pronunciation
U.S. Brand Names
Generic Available
Pharmacological Index
Use
Pregnancy Risk Factor
Usual Dosage
Dental Health: Local Anesthetic/Vasoconstrictor Precautions
Dental Health: Effects on Dental Treatment
Dosage Forms

Pronunciation
(klor fen IR a meen, fen il EF rin, & fen il tole LOKS a meen)

U.S. Brand Names
Comhist®; Comhist® LA

Generic Available

No


Pharmacological Index

Antihistamine/Decongestant Combination


Use

Symptomatic relief of rhinitis and nasal congestion due to colds or allergy


Pregnancy Risk Factor

C


Usual Dosage

Oral: 1 capsule every 8-12 hours or 1-2 tablets 3 times/day


Dental Health: Local Anesthetic/Vasoconstrictor Precautions

Use with caution since phenylephrine is a sympathomimetic amine which could interact with epinephrine to cause a pressor response


Dental Health: Effects on Dental Treatment

Chlorpheniramine: Prolonged use will cause significant xerostomia

Phenylephrine: Up to 10% of patients could experience tachycardia, palpitations, and dry mouth; use vasoconstrictor with caution


Dosage Forms

Capsule, sustained release (Comhist® LA): Chlorpheniramine maleate 4 mg, phenylephrine hydrochloride 20 mg, and phenyltoloxamine citrate 50 mg

Tablet (Comhist®): Chlorpheniramine maleate 2 mg, phenylephrine hydrochloride 10 mg, and phenyltoloxamine citrate 25 mg


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