Yes

Antihypertensive Agent, Combination

Management of hypertension and treatment of congestive heart failure

C/D (2nd and 3rd trimesters)

Hypersensitivity to captopril, hydrochlorothiazide or any component

Captopril:

1% to 10%:

Cardiovascular: Tachycardia, chest pain, palpitations

Central nervous system: Insomnia, headache, dizziness, fatigue, malaise

Dermatologic: Rash, pruritus, alopecia

Gastrointestinal: Abdominal pain, vomiting, nausea, diarrhea, anorexia, constipation, dysgeusia

Neuromuscular & skeletal: Paresthesias

Renal: Oliguria

Respiratory: Transient cough

<1%:

Cardiovascular: Hypotension

Dermatologic: Angioedema

Endocrine & metabolic: Hyperkalemia

Gastrointestinal: Dysgeusia

Hematologic: Neutropenia, agranulocytosis

Renal: Proteinuria, elevated BUN, serum creatinine

Hydrochlorothiazide:

1% to 10%: Endocrine & metabolic: Hypokalemia

<1%:

Cardiovascular: Hypotension

Dermatologic: Photosensitivity

Endocrine & metabolic: Fluid and electrolyte imbalances (hypocalcemia, hypomagnesemia, hyponatremia), hyperglycemia

Hematologic: Rarely blood dyscrasias

Renal: Prerenal azotemia

Probenecid increases blood levels of captopril. Increased serum lithium levels and symptoms of lithium toxicity have been reported in patients receiving concomitant lithium and ACE inhibitor therapy. Hydrochlorothiazide decreases antidiabetic drug efficacy. Hydrochlorothiazide has been reported to increase digoxin-related cardiac arrhythmias

Captopril is a competitive inhibitor of angiotensin-converting enzyme (ACE); prevents conversion of angiotensin I to angiotensin II, a potent vasoconstrictor. This results in lower levels of angiotensin II which causes an increase in plasma renin activity and a reduction in aldosterone secretion. Hydrochlorothiazide inhibits sodium reabsorption in the distal tubules causing increased excretion of sodium and water as well as potassium and hydrogen ions.

Adults: Oral:

Combination therapy for the treatment of hypertension should be individualized for each patient. Potential advantages for captopril and hydrochlorothiazide combination therapy may include improved compliance and synergistic reductions in blood pressure with an accomplished reduction in side effects.

No information available to require special precautions

No effects or complications reported

See individual agents. Pregnancy precautions: Inform prescriber if you are or intend to be pregnant.

Tablet:

25/25: Captopril 25 mg and hydrochlorothiazide 25 mg

50/15: Captopril 50 mg and hydrochlorothiazide 15 mg

50/25: Captopril 50 mg and hydrochlorothiazide 25 mg