Enzyme (ACE) Inhibitors
A case of cough induced by topical capsaicin cream (0.075%) has been reported
in a patient taking an ACE inhibitor (Hakas 1990). A 53-year-old female patient
applied capsaicin cream to her lower extremities for the treatment of peripheral
neuropathy secondary to diabetes. She had been maintained on an ACE inhibitor
for several years without experiencing cough as a side effect prior to the
introduction of the capsaicin. The cough was temporally related to application
of the capsaicin
In a clinical trial involving 18 healthy volunteers, capsaicin reduced
gastric mucosal damage induced by aspirin (Yeoh et al. 1995). Endoscdopic
examination revealed that oral administration of 20 g of chili (equivalent to
9.65 mg capsaicin) 30 minutes prior to ingesting aspirin (600 mg) reduced
gastric mucosal lesions.
Cayenne enhanced theophylline absorption and bioavailability when
administered orally to rabbits (Bouraoui et al. 1988). High or regular use of
cayenne may increase the risk of theophylline toxicity, although this has not
been tested in humans.
Bouraoui A, Toumi A, Mustapha HB, et al. Effects of capsicum fruit on
theophylline absorption and bioavailability in rabbits. Drug-Nutrient
Hakas JF. Topical capsaicin induces cough in a patient receiving ACE
inhibitor. Ann Allergy. 1990;65:322.
Yeoh KG, et al. Chili protects against aspirin-induced gastroduodenal mucosal
injury in humans. Dig Dis Sci.
Copyright © 2000 Integrative Medicine
CommunicationsThis publication contains
information relating to general principles
of medical care that should not in any event be construed as specific
instructions for individual patients. The publisher does not accept any
responsibility for the accuracy of the information or the consequences arising
from the application, use, or misuse of any of the information contained herein,
including any injury and/or damage to any person or property as a matter of
product liability, negligence, or otherwise. No warranty, expressed or implied,
is made in regard to the contents of this material. No claims or endorsements
are made for any drugs or compounds currently marketed or in investigative use.
The reader is advised to check product information (including package inserts)
for changes and new information regarding dosage, precautions, warnings,
interactions, and contraindications before administering any drug, herb, or
supplement discussed herein.