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Creatine | ||
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Tyrosine | ||
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| Pronunciation |
 (brome
fen IR a meen & fen il proe
pa NOLE a meen) |
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| U.S. Brand Names |
| Bromaline® Elixir [OTC]; Bromanate® Elixir [OTC]; Bromatapp®[OTC]; Bromphen® Tablet [OTC]; Cold & Allergy® Elixir [OTC]; Dimaphen® Elixir [OTC]; Dimaphen® Tablets [OTC]; Dimetapp® 4-Hour Liqui-Gel Capsule [OTC]; Dimetapp® Elixir [OTC]; Dimetapp® Extentabs®[OTC]; Dimetapp® Tablet [OTC]; Genatap® Elixir [OTC]; Tamine®[OTC]; Vicks® DayQuil® Allergy Relief 4 Hour Tablet [OTC] |
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| Generic Available |
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Yes |
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| Synonyms |
| Phenylpropanolamine and Brompheniramine |
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| Pharmacological Index |
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Antihistamine/Decongestant Combination |
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| Use |
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Temporary relief of nasal congestion, running nose, sneezing, and itchy, watery eyes |
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| Pregnancy Risk Factor |
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B |
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| Adverse Reactions |
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>10%: Cardiovascular: Tachycardia Central nervous system: Slight to moderate drowsiness, nervousness, transient stimulation, insomnia Respiratory: Thickening of bronchial secretions 1% to 10%: Central nervous system: Headache, fatigue, dizziness Gastrointestinal: Appetite increase, weight increase, nausea, diarrhea, abdominal pain, dry mouth Genitourinary: Dysuria Neuromuscular & skeletal: Arthralgia, weakness Respiratory: Pharyngitis Miscellaneous: Sweating <1%: Central nervous system: Depression, sedation, paradoxical excitement, convulsions, hallucinations Cardiovascular: Edema, palpitations, hypotension Dermatologic: Angioedema, rash, photosensitivity Genitourinary: Urinary retention Hepatic: Hepatitis Neuromuscular & skeletal: Myalgia, paresthesia, tremor Ocular: Blurred vision Respiratory: Bronchospasm, epistaxis, dyspnea |
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| Drug Interactions |
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Increased risk of hypertension: MAO inhibitors (hypertensive crisis, severe headache, hyperpyrexia possible), guanethidine, methyldopa Increased toxicity with CNS depressants, sympathomimetics, TCAs, anticholinergics Decreased decongestant activity with phenothiazines, rauwolfia alkaloids |
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| Usual Dosage |
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Oral: 1-6 months: 1.25 mL 3-4 times/day 7-24 months: 2.5 mL 3-4 times/day 2-4 years: 3.75 mL 3-4 times/day 4-12 years: 5 mL 3-4 times/day Adults: 5-10 mL 3-4 times/day or 1 regular tablet every 4 hours; sustained release: 1 tablet every 12 hours |
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| Dental Health: Local Anesthetic/Vasoconstrictor Precautions |
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Brompheniramine: No information available to require special precautions Phenylpropanolamine: Use with caution since phenylpropanolamine is a sympathomimetic amine which could interact with epinephrine to cause a pressor response |
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| Dental Health: Effects on Dental Treatment |
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Brompheniramine: Prolonged use may decrease salivary flow Phenylpropanolamine: Up to 10% of patients could experience tachycardia, palpitations, and dry mouth; use vasoconstrictor with caution |
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| Patient Information |
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Take with food |
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| Nursing Implications |
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Swallow tablet whole, do not crush or chew |
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| Dosage Forms |
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Capsule (Dimetapp® 4-Hour Liqui-Gel): Brompheniramine maleate 4 mg and phenylpropanolamine hydrochloride 25 mg Liquid (Bromaline®, Bromanate®, Cold & Allergy®, Dimaphen®, Dimetapp®, Genatap®): Brompheniramine maleate 2 mg and phenylpropanolamine hydrochloride 12.5 mg per 5 mL Tablet (Dimaphen®, Dimetapp®, Vicks® DayQuil® Allergy Relief 4 Hour): Brompheniramine maleate 4 mg and phenylpropanolamine hydrochloride 25 mg Tablet, sustained release: Brompheniramine maleate 12 mg and phenylpropanolamine hydrochloride 75 mg |
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