Experimental findings have demonstrated that idrocilamide exhibits antiinflammatory and muscle
relaxant properties due at least in part to tissular effects.
المقال ده عباره عن دراسه عن العقار واللى بتقول انه يعتبر مضاد التهاب وباسط للعضلات وتاثيرو بيكون واضح اكتر ع العضلات
Percutaneous diffusion of a 10% glycero-alcoholic idrocilamide solution was studied in ten patients scheduled to undergo total knee replacement. Four 200-mg doses of idrocilamide were applied to the suprapatellar area at 12-hour intervals before surgery
فهمول دراسه الجليسرو الكحول ده عباره عن المزيب وحقنو الدوا عن طريق ماقبل تحت الجلد ( مش عارفه معناها العلمى ) بيحقنو 200كج من الدوا ق منطقه معينه (لوتركم دوك احمد يقولها انا شاكه انها تبع التشريح )
جرعه كل 12 ساعه قبل العمليه
. Pain was evaluated using a visual analog scale before and after treatment. Surgery was performed 1.75 to 3.5 hours after the last idrocilamide dose. Idrocilamide was assayed using high performance liquid chromatography in tissue, plasma, and joint fluid specimens taken during the surgical procedure.
وبعد الملاحظات قبل وبعد العلاج بعد تعاطى الدوا ب 3.5 وقاسو نسبه العقار ب HPLC وجدو انو الدوا موجود ف الانسجه والدم والمفاصل
Topical administration of idrocilamide on healthy skin produced significant concentrations of the drug in all the tissue specimens, including subcutaneous fat, muscle, tendon, synovium, and knee capsule.
وبالتالى توصلنا انو العقار ده لو اتاخد عن طريق الجلد الصحيح ووضع موضعيا فسوف نجد تركيز ملحوظ منو فى اغلب الانسجه والتى تشمل الاربطه والمفاصل والركبه
Tissue levels were consistently higher than synovial fluid and plasma levels, indicating that little systemic diffusion occurred. Idrocilamide levels in potential target tissues might influence clinical effects
وبالتالى التركيز العالى للعقار فى الانسجه اكتر من الsynovial fluid يشير الى انو يوجد ايضا بعد الاحتمالات من وصول العقار للدوره الدمويه وبالتالى مكن يكون ليه بعض التاثيرات الاخرى
سورى دوك حازم اتمنى اكون قدرت اترجم وقدرت اوضح الفكره شويه ... انا كمان فى مصطلحات مش اعرف ترجمتها بالعربيه كمصطلح طبى
لذا ارجو يكون وضح المقال .... وان شاء الله لو عندك اى استفسار لسه ..ربنا يقدرنى وافهم واحاول اعرضلكو اللى فهمتو
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التعليقات
الدوا ده عندنا ف مصر باسم تجارى اسمو ........... عباره عن كريم مسكن ومضاد للالتهاب وباسط موضعى للعضلات
اما بالنسبه لميكانيكيه العمل .. انا بحثت وحاولت اعرف لكنى مش قدرت اتوصل غير للمعلومات دى ... بكره ان شاء الله اشوف ال leaflet واكتبهالكو ا ...
Licenser Merck
Ingredient Idrocilamide 5%
Category Topical muscle relaxant for musculo-skeletal spasm
Pharm. Form Tube of 20 g cream
Indications
This drug is recommended in adults and children over 15 years of age, as local adjunct short-term treatment in:
•Benign joint injuries of the common ankle sprain type and contusions
•Acute lower back pain
Contraindications
This drug should not be used in the following cases:
•History of allergy to one of the components of the cream
•Injured skin, regardless of the lesion: weeping lesions, eczema, infected lesions, burns or open wounds
•Children under 15 years of age
Dosage & Administration
Cutaneous route. Apply as local massages to the painful area, 1 to 3 times daily, until completely rubbed in. Wash hands after use.
Do not apply more than 3 times daily
Warnings
•Do not apply to mucous membranes of the eyes
•The hands must be washed after use to avoid any involuntary contact of the product with the eyes or mucous membranes
لكنى نسيت اليوم ... بكره ان شاء الله هشوفها ومش هنسى ان شاء الله
Fifty-one spastic patients, divided into four groups, were tested. All four drugs reduced the H/M and T/M ratios very slightly.
Only diazepam and tizanidine reinforced vibratory inhibition.
Diazepam and tizanidine did not modify the abnormal recovery curves, however,
whereas baclofen and idrocilamide did.
Reinforcement of vibratory inhibition suggests an increase in presynaptic inhibition mediated by gamma-aminobutyric acid; changes in recovery curves are likely due to modifications of interneuronal reactivity.
Matching myorelaxants to the predominant pathophysiological abnormality detected by electrophysiological exploration may lead to better treatment of spasticity.
اعتقد ده هلاقيه ف المرجع ماتن دل اللى بمكتبه الكليه ... هحط الموصوع ف دماغى لحد ما انزل الكليه واكيد هوصل ان شاء الله
لكنى هضل فاكره لحد ما انزل الكليه اشوف الفارماكوبيا .... اكيد هلاقى