Class: Narcotic antagonist.
Trade names: Narcan
Block the action of narcotic analgesic by displacing previously given narcotics from their receptor sites or preventing them from attaching to opiate receptors.
The duration of action of naloxone is shorter than that of the narcotic analgesic so the respiratory depression may return when the narcotic antagonist has washed off the body.
§ Diagnosis of acute opiate overdose.
By intravenous injection, 100–200 micrograms (1.5–3 micrograms/kg); if response inadequate, increments of 100 micrograms every 2 minutes; further doses by intramuscular injection after 1–2 hours if required
CHILD by intravenous injection, 10 micrograms/kg; subsequent dose of 100 micrograms/kg if no response; if intravenous route not possible, may be given in divided doses by intramuscular or subcutaneous injection
NEONATE by subcutaneous, intramuscular, or intravenous injection, 10 micrograms/kg, repeated every 2 to 3 minutes or by intramuscular injection, 200 micrograms (60 micrograms/kg) as a single dose at birth (onset of action slower)
· Sensitivity to drug.
· Narcotic addicts since it will cause sever withdrawal symptoms.
- Nausea, vomiting, sweating, hypertension, tremors.
- If used postoperatively: tachycardia, pulmonary edema, hypo or
· Determine the etiology of respiratory depression.
· Assess & obtain baseline vital signs.
· Monitor respiration closely after the duration of action.
· Have emergency drugs & equipment available.
· If the patient is comatosed, turn him to his side to avoid aspiration.
· Maintain safe environment (side rails & soft support).