dr.joandr.joan عضو ماسي
تم تعديل 2009/07/02 في أدوية الطوارئ Emergency drugs
Naloxane :
Trade names: Narcan
Class: Narcotic antagonist.
Pregnancy: (Category B)
  • Block the action of narcotic analgesic by displacing previously given narcotics from their receptor sites or preventing them from attaching to opiate receptors.
  • The duration of action of naloxone is shorter than that of the narcotic analgesic so the respiratory depression may return when the narcotic antagonist has washed off the body.
  • Respiratory depression induced by narcotics.
  • Drug of choice when the depressant drug is unknown.
§ Diagnosis of acute opiate overdose.
  • By intravenous injection, 100–200 micrograms (1.5–3 micrograms/kg); if response inadequate, increments of 100 micrograms every 2 minutes; further doses by intramuscular injection after 1–2 hours if required
  • CHILD by intravenous injection, 10 micrograms/kg; subsequent dose of 100 micrograms/kg if no response; if intravenous route not possible, may be given in divided doses by intramuscular or subcutaneous injection
  • NEONATE by subcutaneous, intramuscular, or intravenous injection, 10 micrograms/kg, repeated every 2 to 3 minutes or by intramuscular injection, 200 micrograms (60 micrograms/kg) as a single dose at birth (onset of action slower)
· Sensitivity to drug.
· Narcotic addicts since it will cause sever withdrawal symptoms.
· Neonates.
Side effects:
- Nausea, vomiting, sweating, hypertension, tremors.
- If used postoperatively: tachycardia, pulmonary edema, hypo or
Nursing considerations:
· Determine the etiology of respiratory depression.
· Assess & obtain baseline vital signs.
· Monitor respiration closely after the duration of action.
· Have emergency drugs & equipment available.
· If the patient is comatosed, turn him to his side to avoid aspiration.
· Maintain safe environment (side rails & soft support).