Cefazolin

dr.joan

Cefazolin:
Trade name: Ancef, Kefzol.
Class: Antibiotic "cephalosporines"FIRST GENERATION
Pregnancy: (Category

Action: Bind to bacterial cell wall membrane, causing cell death.
Uses:
Treatment of:
· Skin and skin structure infections (including burn wounds)
· Pneumonia.
· Otitis media.
· Urinary tract infections.
· Bone and joint infections.
· Septicemia (including endocarditic) caused by susceptible organisms.
· Perioperative prophylaxis.
Dose
By intramuscular injection or intravenous injection or infusion, 0.5–1 g every 6–12 hours; CHILD, 25–50 mg/kg daily (in divided doses), increased to 100 mg/kg daily in severe infections
Contraindications:
· Hypersensitivity to cephalosporin or Penicillin, renal failure, Pregnancy, Lactation.


Side effects:
· Nausea, vomiting, diarrhea, anorexia, abdominal pain, flatulence, skin rashes super-infection, heartburn, sore mouth, bone marrow depression: (Decrease WBC, decreased platelets, decreased Hct), Nephrotoxicity, (pain, abscess at injection site, phlebitis and inflammation at IV site.
Nursing considerations:

• Infuse over 30 minutes unless otherwise indicated.
• Therapy should be continued for at least 2-3 days after symptoms of infection have disappeared.
• Assess client with a history of hypersensitivity reaction. “for penicillin or cephalosporin.”
• Assess client financial status. These drugs are usually expensive.
• If GI upset occurs administer. Drugs with meals. “Should be administered on empty stomach”.

Obtain liver & renal studies.