Amikacin Sulfate

dr.joan

5. Amikacin Sulfate:
Trade name: amikin
Class: Antibiotic "Amino glycosides"
Pregnancy: (Category C)
Action: inhibit protein synthesis by binding irreversibly to ribosome which leads to production of nonfunctional protein. They are usually bactericidal as a result of disruption of bacterial cytoplasmic membrane.

Uses:

• Bone and joint infections.
• Respiratory tract infections.
• Septicemia (including neonatal sepsis).
• Urinary tract infection (UIT).
• Post operative infections.
• Intra –abdominal infections (as peritonitis) .
• Skin infections (including burns)

Dose : by intramuscular or by slow intravenous injection or by infusion, 15 mg/kg daily in 2 divided doses, increased to 22.5 mg/kg daily in 3 divided doses in severe infections; max. 1.5 g daily for up to 10 days (max. cumulative dose 15 g); child 15 mg/kg daily in 2 divided doses; neonate loading dose of 10 mg/kg then 15 mg/kg daily in 2 divided doses.

Contraindications:

• Hypersensitivity to amino glycosides.
• Long –term therapy.
• For patients with impaired renal function or pre-existing hearing impairment.

Side effects:

• Ototoxicity: tinnitus, hearing impairment, ataxia & dizziness.
• Renal impairment (Nephrotoxicity) hematuria, proteinuria…
• Neurotoxicity: headache, tremor, lethargy, numbness, burning of face.
• Others: nausea, vomiting, skin rash & super infection.

Nursing considerations:

· I.M. admin. Inject deep into muscle to minimize pain.
· Admin. For only 7-10 days.
· Assess history of hypersensitivity.
· Obtain lab. Studies for renal function.
· Continue to monitor for ototoxicity.
· Discuss with the client / family the importance of taking medications at the appropriate prescribed time intervals.

الفتاة الحالمة

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