Allopurinol : Zyloric

dr.joan

5. Allopurinol : Zyloric
Trade name: Zyloric
Class: Anti-gout Agents
Pregnancy: (Category C)

Action: Is a potent xanthine oxidase inhibitor which reduces both serum and urinary uric acid levels by inhibiting the formation of uric acid without disrupting the biosynthesis of vital purines.
Uses:
· Is the drug of choice for chronic gouty arthritis (not useful for treatment of acute gout).
· Hyperuricemia associated with blood diseases, renal diseases.
· Prophylasis in hyperuricemia in patients with neoplastic conditions.
· Treatment of patients with recurrent uric stone formation.
Dose
initially 100 mg daily, preferably after food, then adjusted according to plasma or urinary uric acid concentration; usual maintenance dose in mild conditions 100–200 mg daily, in moderately severe conditions 300–600 mg daily, in severe conditions 700–900 mg daily; doses over 300 mg daily given in divided doses; CHILD under 15years, (in neoplastic conditions, enzyme disorders) 10–20 mg/kg daily (max. 400 mg daily)
Contraindications:
· Hypersensitivity.
· Lactation.
· Hemochromatosis.
· Children except for those with neoplastie diseases.
Side effects:
· Skin rash, alopecia, fever leukopnea, arthralgia, nausea, vomiting.
Nursing considerations:
· Administer with food or immediately after meal to lessen gastric irritation.
· At least 10-12 eight- ounce glasses of fluid should be taken each day.
· Keep urine alkaline to prevent the formation of uric acid stones.
· Take complete drug history.
· Monitor the CBC, liver & renal function & serum uric acid on routine bases.
· If skin rash appear, report to physician.
· Avoid excessive intake of vitamin C which lead to the potential for the formation of kidney stones.
· Advice clients not to take iron salts with allopurinol since high iron concentration may occur in the liver.

الفتاة الحالمة

[align=center]Thank you dr
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