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Interactions
with Manganese | |
Haloperidol
In one case report, a patient with progressive hepatic failure who received
haloperidol and manganese as part of total parenteral nutrition exhibited
neuropsychiatric symptoms (Mehta and Reilly 1990). Toxic manganese levels may
have increased the patient's susceptiblity to haloperidol toxicity.
Phenobarbital
Simultaneous administration of phenobarbital and manganese (5 mg/kg)
prevented manganese-induced prolongation of hexobarbital hypnosis in male rats
(Deimling and Schnell 1983). |
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References |
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Deimling MJ, Schnell C. Interaction between manganese and phenobarbital on
hexobarbital hypnosis in the male rat. Res Commun Chem Pathol Pharmacol.
1983;41(1):165-168.
Mehta R, Reilly JJ. Manganese levels in a jaundiced long-term total
parenteral nutrition patient: Potentiation of haloperidol toxicity?: Case report
and literature review. J Parenter Enter Nutr.
1990;14(4):428-430. |
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