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Interactions
with Ethylenediaminetetraacetic Acid
(EDTA) | |
Cefmetazole
Cefmetazole (0.2 mL of 10 mM solution) was absorbed more rapidly in the rat
jejunum and colon when administered with EDTA (67 mM) (Suzuka et al. 1985). EDTA
may enhance the intestinal absorption of hydrophilic compounds by chelating
calcium ions in the tight junctional area. Another in vitro study in rats using
the colonic sac method demonstrated that the transport of cefmetazole (800
mg/mL) from the mucosal to serosal medium was increased in the presence of EDTA
(50 mM) (Suzuka et al. 1987). |
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References |
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Suzuka T, Furuya A, Kamada A, Nishihata T. Effect of phenothiazines, disodium
ethylenediaminetetraacetic acid and diethyl maleate on the in vitro rat
colonic transport of cefmetazole and inulin. J.Pharmacobio-Dyn.
1987;10:63-71.
Suzuka T, Nishihata T, Yamazaki M, Kamada A. Effect of salicylate and
disodium EDTA on the rat intestinal absorption of cefmetazole. Chem
Pharm Bull. 1985;33:4600-4605. |
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