|
|
Interactions
with Alpha-Lipoic Acid | |
Amikacin;
Gentamicin
Supplementation with alpha-lipoic acid (100 mg/kg/day) in rats treated with
amikacin significantly reduced cochlear damage caused by ototoxic doses of this
drug (Conlon et al. 1999). Treatment with alpha-lipoic acid (25 mg/kg/day) also
ameliorated the oxidative stress caused by gentamicin (100 mg/kg/day) in rats
(Sandhya and Varalakshmi 1997). Gentamicin-induced oxidative stress is thought
to underlie the potentially serious renal side effects associated with this
drug. Cisplatin
A study comparing alpha-lipoic acid at several different doses (25 to 100
mg/kg), with and without cisplatin, concluded that the alpha-lipoic acid
conferred significant protection against cisplatin ototoxicity at all dose
levels in rats (Rybak et al. 1999). This effect was associated with improvements
in glutathione metabolic markers and reduced oxidative stress.
Cyclophosphamide
Preclinical evidence suggests that alpha-lipoic acid may protect against the
cytotoxic effects induced by cyclophosphamide (Faust et al. 1994).
Supplementation with alpha-lipoic acid significantly reduced the incidence of
cyclophosphamide-induced diabetes in mice.
Levothyroxine
In rats, alpha-lipoic acid (7.5 mg/100 g/day) inhibited enzymatic conversion
of triiodothyronine (T3) to thyroxine (T4) (Segermann et
al. 1991). Alpha-lipoic acid supplementation with T4 also had an
apparent synergistic effect on serum cholesterol, producing significantly
greater depression than T4 alone. Blood hormone levels and thyroid
function tests should be monitored for this potential
interaction. |
|
|
References |
|
Conlon BJ, Aran JM, Erre JP, et al. Attenuation of aminoglycoside-induced
cochlear damage with the metabolic antioxidant alpha-lipoic acid. Hear
Res. 1999;128:40-44.
Faust A, Burkart V, Ulrich H, et al. Effect of lipoic acid on
cyclophosphamide-induced diabetes and insulitis in non-obese diabetic mice.
Int J Immunopharmacol. 1994;16:61-66.
Rybak LP, Husain K, Whitworth C, et al. Dose dependent protection by lipoic
acid against cisplatin-induced ototoxicity in rats: antioxidant defense system.
Toxicol Sci. 1999;47:195-202.
Sandhya P, Varalakshmi P. Effect of lipoic acid administration on
gentamicin-induced lipid peroxidation in rats. J Appl Toxicol.
1997;17:405-408.
Segermann J, Hotze A, Ulrich H, et al. Effect of alpha-lipoic acid on the
peripheral conversion of thyroxine to triiodothyronine and on serum lipid-,
protein- and glucose levels. Arzneimittelforschung.
1991;41:1294-1298. |
|
Copyright © 2000 Integrative Medicine
Communications This publication contains
information relating to general principles
of medical care that should not in any event be construed as specific
instructions for individual patients. The publisher does not accept any
responsibility for the accuracy of the information or the consequences arising
from the application, use, or misuse of any of the information contained herein,
including any injury and/or damage to any person or property as a matter of
product liability, negligence, or otherwise. No warranty, expressed or implied,
is made in regard to the contents of this material. No claims or endorsements
are made for any drugs or compounds currently marketed or in investigative use.
The reader is advised to check product information (including package inserts)
for changes and new information regarding dosage, precautions, warnings,
interactions, and contraindications before administering any drug, herb, or
supplement discussed herein. | |