Interactions with Vitamin B9 (Folic Acid)

In a randomized, double-blind, placebo-controlled study, folic acid supplementation (27.5 mg/week for 53 weeks) in 79 patients with rheumatoid arthritis countered the adverse effects of methotrexate without compromising therapeutic efficacy (Morgan et al. 1994).

Tetracycline

In one study, the bioavailability of tetracycline hydrochloride was reduced significantly by concomitant administration of vitamin B complex to healthy subjects (Omray 1981). Patients should be cautioned to take vitamin B complex supplements at different times from tetracycline.

References

Morgan S, Baggott J, Vaughn W, et al. Supplementation with folic acid during methotrexate therapy for rheumatoid arthritis. Ann Intern Med. 1994;121:833-841.

Omray A. Evaluation of pharmacokinetic parameters of tetracylcine hydrochloride upon oral administration with vitamin C and vitamin B complex. Hindustan Antibiot Bull. 1981;23(VI):33-37.

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