with Vitamin B2 (Riboflavin)|
Supplementation with vitamins B1, B2, and B6 (10 mg each) at the start of
tricyclic antidepressant therapy improved cognitive functioning and depression
ratings in 14 geriatric patients undergoing treatment with nortriptyline
titrated to doses yielding blood levels between 50 to 150 ng/mL (Bell, et al.
1992). B vitamins may augment the treatment of depression in elderly
Children receiving the anticonvulsant drug diphenylhydantoin have displayed
subnormal urinary excretions of riboflavin (Lewis et al. 1975).
In one study, the bioavailability of tetracycline hydrochloride was reduced
significantly by concomitant administration of vitamin B complex to healthy
subjects (Omray 1981). Patients should be cautioned to take vitamin B complex
supplements at different times from tetracycline.
Bell, IR, Edman JS, Morrow FD, et al. Brief communication. Vitamin B1, B2,
and B6 augmentation of tricyclic antidepressant treatment in geriatric
depression with cognitive dysfunction. J Am Coll Nutr.
Lewis JA, Baer MT, Laufer MA. Urinary riboflavin and creatinine excretion in
children treated with anticonvulsant drugs [letter]. Am J Dis Child.
Omray A. Evaluation of pharmacokinetic parameters of tetracylcine
hydrochloride upon oral administration with vitamin C and vitamin B complex.
Hindustan Antibiot Bull.
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