with Vitamin B1 (Thiamine)|
Supplementation with vitamins B1, B2, and B6 (10 mg each) at the start of
tricyclic antidepressant therapy improved cognitive functioning and depression
ratings in 14 geriatric patients undergoing treatment with nortriptyline
titrated to doses yielding blood levels between 50 to 150 ng/mL (Bell et al.
1992). B vitamins may augment the treatment of depression in elderly
In a randomized, double-blind, placebo-controlled, double-crossover clinical
trial with 13 healthy subjects, coadministration of thiamine (5 g po) countered
the cognitive side effects associated with scopolamine treatment (0.007 mg/kg
IM) as compared to placebo (Meador et al. 1993).
In one study, the bioavailability of tetracycline hydrochloride was reduced
significantly by concomitant administration of vitamin B complex to healthy
subjects (Omray 1981). Patients should be cautioned to take vitamin B complex
supplements at different times from tetracycline.
Bell I, Edman J, Morrow F, et al. Brief communication. Vitamin B1, B2, and B6
augmentation of tricyclic antidepressant treatment in geriatric depression with
cognitive dysfunction. J Am Coll Nutr. 1992;11:159-163.
Meador KJ, Nichols ME, Franke P, et al. Evidence for a central cholinergic
effect of high-dose thiamine. Ann Neurol. 1993;34:724-726.
Omray A. Evaluation of pharmacokinetic parameters of tetracycline
hydrochloride upon oral administration with vitamin C and vitamin B complex.
Hindustan Antibiot Bull.
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