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Interactions
with Omega-6 Fatty Acids | |
Cyclosporine
Rats receiving cardiac allografts that were fed a diet high in omega-6
polyunsaturated fatty acids had a significantly prolonged median graft survival
rate (14.5 days) compared to animals fed either lab chow or a diet high in
monounsaturated fatty acids and saturated fat (Haw et al. 1995). The group
treated with omega-6 had significantly higher myocardial blood flow after
cyclosporine administration than the group fed the diet of saturated fat.
Omega-6 fatty acids exhibited immunosuppressive effects because lymphocyte
responses were suppressed to a greater extent in animals treated with these
fatty acids. |
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References |
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Haw M, Linnebjerg H, Chavali SR, Forse RA. The effect of dietary
polyunsaturated fatty acids (PUFA) on acute rejection and cardiac allograft
blood flow in rats. Transplantation.
1995;60(6):570-577. |
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