Manganese
  Uses of this Supplement
Atherosclerosis
Diabetes Mellitus
Hypercholesterolemia
Osteoporosis
Rheumatoid Arthritis
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  Drugs that Interact
Summary
Haloperidol
Phenobarbital
Phenobarbital-containing Medications
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Nutrition
Look Up > Supplements > Manganese > Interactions
Interactions with Manganese
Haloperidol

In one case report, a patient with progressive hepatic failure who received haloperidol and manganese as part of total parenteral nutrition exhibited neuropsychiatric symptoms (Mehta and Reilly 1990). Toxic manganese levels may have increased the patient's susceptiblity to haloperidol toxicity.

Phenobarbital

Simultaneous administration of phenobarbital and manganese (5 mg/kg) prevented manganese-induced prolongation of hexobarbital hypnosis in male rats (Deimling and Schnell 1983).


References

Deimling MJ, Schnell C. Interaction between manganese and phenobarbital on hexobarbital hypnosis in the male rat. Res Commun Chem Pathol Pharmacol. 1983;41(1):165-168.

Mehta R, Reilly JJ. Manganese levels in a jaundiced long-term total parenteral nutrition patient: Potentiation of haloperidol toxicity?: Case report and literature review. J Parenter Enter Nutr. 1990;14(4):428-430.


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