Interactions with Ethylenediaminetetraacetic Acid (EDTA)

Cefmetazole (0.2 mL of 10 mM solution) was absorbed more rapidly in the rat jejunum and colon when administered with EDTA (67 mM) (Suzuka et al. 1985). EDTA may enhance the intestinal absorption of hydrophilic compounds by chelating calcium ions in the tight junctional area. Another in vitro study in rats using the colonic sac method demonstrated that the transport of cefmetazole (800 mg/mL) from the mucosal to serosal medium was increased in the presence of EDTA (50 mM) (Suzuka et al. 1987).

References

Suzuka T, Furuya A, Kamada A, Nishihata T. Effect of phenothiazines, disodium ethylenediaminetetraacetic acid and diethyl maleate on the in vitro rat colonic transport of cefmetazole and inulin. J.Pharmacobio-Dyn. 1987;10:63-71.

Suzuka T, Nishihata T, Yamazaki M, Kamada A. Effect of salicylate and disodium EDTA on the rat intestinal absorption of cefmetazole. Chem Pharm Bull. 1985;33:4600-4605.

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