In a double-blind, clinical study with 127 patients, coadministration of
bromelain (80 mg po) and amoxicillin (500 mg) increased concentrations of the
antibiotic in the blood, organs, and tissues three and six hours after treatment
(Tinozzi and Venegoni 1978). More research is needed to confirm these
Bromelain may increase the absorption and bioavailability of tetracycline. A
randomized study involving 36 patients with chlamydia infections investigated
the efficacy of tetracycline hydrochloride (1000 mg/day) plus bromelain (160
mg/day) against treatment with doxycycline (200 mg/day) alone (Sanders 1990).
After one week, the infectious pathogen was eliminated in 66.7% of patients in
the tetracycline plus bromelain group as compared to 55.6% in the doxycycline
group; by day 14, no infection was detected in either group. However, an earlier
study reported no effect on absorption or elimination of tetracycline when
patients were coadministered bromelain (80 mg) with tetracycline (500 mg)
Bradbrook JD. The effect of bromelain on the absorption of orally
administered tetracycline. Br J Clin Pharmacol. 1978;6(6):552-554.
Sanders HJ. Therapy of chlamydia infections with tetracyclines. Int J Exp
Clin Chemother. 1990;3(2):101-106.
Tinozzi S, Venegoni A. Efffect of bromelain on serum and tissue levels of
amoxycillin. Drugs Exptl. Clin. Res. 1978;
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