|
|
Interactions
with Wild Yam | |
Estradiol
Dietary provisions of diosgenin (1% w/w) for 6 days reduced the cholestatic
effects of
estradiol-17b-(b-D-glucuronide)
(1.1 mmol/100g IV) in rats (Accatino et al. 1998). In
addition, the diosgenin-supplemented diet prevented some of the cholestatic
effects of 17 a-ethynylestradiol (5 mg/kg
subcutaneously), such as increased biliary alkaline phosphatase and decreased
taurocholate SRm. |

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References |
|
Accatino L, Pizarro M, Solis N, Koenig C. Effects of diosgenin, a plant
derived steroid, on bile secretion and hepatocellular cholestasis induced by
estrogens in the rat. Hepatol.
1998;28(1):129-140. |

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