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Irritable Bowel Syndrome
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Look Up > Herbs > Peppermint > Interactions
Interactions with Peppermint

In a study evaluating potential essential oils as transdermal delivery agents, peppermint oil acted as a penetration enhancer for 5-fluorouracil (5-FU) using excised rat skin (Abdullah et al. 1996). Peppermint oil enhanced the permeation of 5-FU approximately 46-fold. The mechanism for the accelerated percutaneous absorption of 5-FU combined with these essential oils may be due to a combination of partition and diffusion.


Abdullah D, Ping QN, Liu GJ. Enhancing effect of essential oils on the penetration of 5-fluorouracil through rat skin. Yao Hsueh Hsueh Pao. 1996;31(3):214-221.

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