In a study evaluating potential essential oils as transdermal delivery
agents, peppermint oil acted as a penetration enhancer for 5-fluorouracil (5-FU)
using excised rat skin (Abdullah et al. 1996). Peppermint oil enhanced the
permeation of 5-FU approximately 46-fold. The mechanism for the accelerated
percutaneous absorption of 5-FU combined with these essential oils may be due to
a combination of partition and diffusion.
Abdullah D, Ping QN, Liu GJ. Enhancing effect of essential oils on the
penetration of 5-fluorouracil through rat skin. Yao Hsueh Hsueh Pao.
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