Yes

Diuretic, Osmotic; Keratolytic Agent; Topical Skin Product

Reduces intracranial pressure and intraocular pressure; topically promotes hydration and removal of excess keratin in hyperkeratotic conditions and dry skin; mild cervicitis

C

Severely impaired renal function, hepatic failure; active intracranial bleeding, sickle cell anemia, topical use in viral skin disease

Urea should not be used near the eyes; use with caution if applied to face, broken, or inflamed skin; use with caution in patients with mild hepatic or renal impairment

1% to 10%:

Endocrine & metabolic: Electrolyte imbalance

Gastrointestinal: Nausea, vomiting

Local: Transient stinging, local irritation, tissue necrosis from extravasation of I.V. preparation

Increased BUN, decreased renal function; treatment is supportive

Decreased effect/toxicity/levels of lithium

Elevates plasma osmolality by inhibiting tubular reabsorption of water, thus enhancing the flow of water into extracellular fluid

Onset of therapeutic effect: I.V.: Maximum effects within 1-2 hours

Duration: 3-6 hours (diuresis can continue for up to 10 hours)

Distribution: Crosses the placenta; appears in breast milk

Half-life: 1 hour

Elimination: Excreted unchanged in urine

Children: I.V. slow infusion:

<2 years: 0.1-0.5 g/kg

>2 years: 0.5-1.5 g/kg

Adults:

I.V. infusion: 1-1.5 g/kg by slow infusion (1-21/2 hours); maximum: 120 g/24 hours

Topical: Apply 1-3 times/day

Vaginal: Insert 1 applicatorful in vagina at bedtime for 2-4 weeks

None reported

May decrease serum lithium levels but overall effect is minimal; do not use for lithium toxicity/overdose; if overdose is associated with severe clinical manifestations, dialysis is the treatment of choice

No information available to require special precautions

No effects or complications reported

Topical: For external use only. Best effect is obtained when applied to skin while still wet or moist after washing or bathing. Do not apply to broken, inflamed, or infected skin. Do not use near eyes. Report skin redness, irritation, or worsening of condition. Breast-feeding precautions: Consult prescriber if breast-feeding.

Vaginal: Wash hands before using. Insert full applicator into vagina gently and expel cream at bedtime. Wash applicator with soap and water following use. Remain lying down for 30 minutes following administration. Report if condition worsens or does not improve.

Do not infuse into leg veins; injection dosage form may be used orally, mix with carbonated beverages, jelly or jam, to mask unpleasant flavor

Cream:

Topical: 2% [20 mg/mL] (75 g); 10% [100 mg/mL] (75 g, 90 g, 454 g); 20% [200 mg/mL] (45 g, 75 g, 90 g, 454 g); 30% [300 mg/mL] (60 g, 454 g); 40% (30 g)

Vaginal: 8.34% [83.4 mg/g] (82.5 g)

Injection: 40 g/150 mL

Lotion: 2% (240 mL); 10% (180 mL, 240 mL, 480 mL); 15% (120 mL, 480 mL); 25% (180 mL)