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Creatine | ||
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| Pronunciation |
 (trye
PROE li deen & soo doe e FED
rin) |
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| U.S. Brand Names |
| Actagen® Syrup [OTC]; Actagen® Tablet [OTC]; Allercon® Tablet [OTC]; Allerfrin® Syrup [OTC]; Allerfrin® Tablet [OTC]; Allerphed® Syrup [OTC]; Aprodine® Syrup [OTC]; Aprodine® Tablet [OTC]; Cenafed® Plus Tablet [OTC]; Genac® Tablet [OTC]; Silafed® Syrup [OTC]; Triofed® Syrup [OTC]; Triposed® Syrup [OTC]; Triposed® Tablet [OTC] |
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| Generic Available |
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Yes |
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| Synonyms |
| Pseudoephedrine and Triprolidine |
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| Pharmacological Index |
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Alpha/Beta Agonist; Antihistamine |
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| Use |
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Temporary relief of nasal congestion, decongest sinus openings, running nose, sneezing, itching of nose or throat and itchy, watery eyes due to common cold, hay fever, or other upper respiratory allergies |
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| Pregnancy Risk Factor |
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C |
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| Contraindications |
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MAO therapy; hypertension; coronary artery disease; hypersensitivity to pseudoephedrine or any component |
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| Adverse Reactions |
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>10%: Cardiovascular: Tachycardia Central nervous system: Slight to moderate drowsiness, nervousness, insomnia, transient stimulation Respiratory: Thickening of bronchial secretions 1% to 10%: Central nervous system: Headache, fatigue, dizziness Gastrointestinal: Appetite increase, weight gain, nausea, diarrhea, abdominal pain, xerostomia Genitourinary: Dysuria Neuromuscular & skeletal: Arthralgia, weakness Respiratory: Pharyngitis Miscellaneous: Diaphoresis |
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| Drug Interactions |
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Decreased effect of guanethidine, reserpine, methyldopa Increased toxicity with MAO inhibitors (hypertensive crisis), sympathomimetics, CNS depressants, alcohol (sedation) |
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| Mechanism of Action |
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Refer to Pseudoephedrine monograph |
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| Usual Dosage |
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Oral: Syrup: 4 months to 2 years: 1.25 mL 3-4 times/day 2-4 years: 2.5 mL 3-4 times/day 4-6 years: 3.75 mL 3-4 times/day 6-12 years: 5 mL every 4-6 hours; do not exceed 4 doses in 24 hours Tablet: 1/2 every 4-6 hours; do not exceed 4 doses in 24 hours Children >12 years and Adults: Syrup: 10 mL every 4-6 hours; do not exceed 4 doses in 24 hours Tablet: 1 every 4-6 hours; do not exceed 4 doses in 24 hours |
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| Dietary Considerations |
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Should be administered with food or milk |
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| Mental Health: Effects on Mental Status |
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Drowsiness, nervousness, and insomnia are common; may cause dizziness; may rarely cause depression, hallucinations, or paradoxical excitement |
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| Mental Health: Effects on Psychiatric Treatment |
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Contraindicated with MAOIs; concurrent use with psychotropics may produce additive sedation |
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| Dental Health: Local Anesthetic/Vasoconstrictor Precautions |
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Use with caution since pseudoephedrine is a sympathomimetic amine which could interact with epinephrine to cause a pressor response |
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| Dental Health: Effects on Dental Treatment |
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Chronic use of antihistamines will inhibit salivary flow, particularly in elderly patients; this may contribute to periodontal disease and oral discomfort |
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| Patient Information |
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May impair ability to perform hazardous activities requiring mental alertness |
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| Nursing Implications |
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Do not crush extended release capsule |
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| Dosage Forms |
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Capsule: Triprolidine hydrochloride 2.5 mg and pseudoephedrine hydrochloride 60 mg Extended release: Triprolidine hydrochloride 5 mg and pseudoephedrine hydrochloride 120 mg Syrup: Triprolidine hydrochloride 1.25 mg and pseudoephedrine hydrochloride 30 mg per 5 mL Tablet: Triprolidine hydrochloride 2.5 mg and pseudoephedrine hydrochloride 60 mg |
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