|
Pronunciation |
|
(trye
PROE li deen & soo doe e FED
rin) |
|
|
U.S. Brand
Names |
|
Actagen® Syrup [OTC]; Actagen®
Tablet [OTC]; Allercon® Tablet [OTC]; Allerfrin® Syrup [OTC];
Allerfrin® Tablet [OTC]; Allerphed® Syrup [OTC];
Aprodine® Syrup [OTC]; Aprodine® Tablet [OTC];
Cenafed® Plus Tablet [OTC]; Genac® Tablet [OTC];
Silafed® Syrup [OTC]; Triofed® Syrup [OTC]; Triposed®
Syrup [OTC]; Triposed® Tablet
[OTC] |
|
|
Generic
Available |
|
Yes |
|
|
Synonyms |
|
Pseudoephedrine and Triprolidine |
|
|
Pharmacological Index |
|
Alpha/Beta Agonist; Antihistamine |
|
|
Use |
|
Temporary relief of nasal congestion, decongest sinus openings, running nose,
sneezing, itching of nose or throat and itchy, watery eyes due to common cold,
hay fever, or other upper respiratory allergies |
|
|
Pregnancy Risk
Factor |
|
C |
|
|
Contraindications |
|
MAO therapy; hypertension; coronary artery disease; hypersensitivity to
pseudoephedrine or any component |
|
|
Adverse
Reactions |
|
>10%:
Cardiovascular: Tachycardia
Central nervous system: Slight to moderate drowsiness, nervousness, insomnia,
transient stimulation
Respiratory: Thickening of bronchial secretions
1% to 10%:
Central nervous system: Headache, fatigue, dizziness
Gastrointestinal: Appetite increase, weight gain, nausea, diarrhea, abdominal
pain, xerostomia
Genitourinary: Dysuria
Neuromuscular & skeletal: Arthralgia, weakness
Respiratory: Pharyngitis
Miscellaneous: Diaphoresis |
|
|
Drug
Interactions |
|
Decreased effect of guanethidine, reserpine, methyldopa
Increased toxicity with MAO inhibitors (hypertensive crisis),
sympathomimetics, CNS depressants, alcohol (sedation) |
|
|
Mechanism of
Action |
|
Refer to Pseudoephedrine monograph |
|
|
Usual Dosage |
|
Oral:
Syrup:
4 months to 2 years: 1.25 mL 3-4 times/day
2-4 years: 2.5 mL 3-4 times/day
4-6 years: 3.75 mL 3-4 times/day
6-12 years: 5 mL every 4-6 hours; do not exceed 4 doses in 24 hours
Tablet: 1/2
every 4-6 hours; do not exceed 4 doses in 24 hours
Children >12 years and Adults:
Syrup: 10 mL every 4-6 hours; do not exceed 4 doses in 24 hours
Tablet: 1 every 4-6 hours; do not exceed 4 doses in 24 hours
|
|
|
Dietary
Considerations |
|
Should be administered with food or milk |
|
|
Mental Health: Effects
on Mental Status |
|
Drowsiness, nervousness, and insomnia are common; may cause dizziness; may
rarely cause depression, hallucinations, or paradoxical
excitement |
|
|
Mental Health:
Effects on Psychiatric
Treatment |
|
Contraindicated with MAOIs; concurrent use with psychotropics may produce
additive sedation |
|
|
Dental Health: Local
Anesthetic/Vasoconstrictor
Precautions |
|
Use with caution since pseudoephedrine is a sympathomimetic amine which could
interact with epinephrine to cause a pressor response |
|
|
Dental Health:
Effects on Dental Treatment |
|
Chronic use of antihistamines will inhibit salivary flow, particularly in
elderly patients; this may contribute to periodontal disease and oral
discomfort |
|
|
Patient
Information |
|
May impair ability to perform hazardous activities requiring mental
alertness |
|
|
Nursing
Implications |
|
Do not crush extended release capsule |
|
|
Dosage Forms |
|
Capsule: Triprolidine hydrochloride 2.5 mg and pseudoephedrine hydrochloride
60 mg
Extended release: Triprolidine hydrochloride 5 mg and pseudoephedrine
hydrochloride 120 mg
Syrup: Triprolidine hydrochloride 1.25 mg and pseudoephedrine hydrochloride
30 mg per 5 mL
Tablet: Triprolidine hydrochloride 2.5 mg and pseudoephedrine hydrochloride
60 mg |
|
Copyright © 1978-2000 Lexi-Comp Inc. All Rights Reserved
|