No

Antiviral Agent, Ophthalmic

Treatment of primary keratoconjunctivitis and recurrent epithelial keratitis caused by herpes simplex virus types I and II

C

Known hypersensitivity to trifluridine or any component

Mild local irritation of conjunctival and cornea may occur when instilled but usually transient effects

1% to 10%: Local: Burning, stinging

<1%: Hyperemia, palpebral edema, epithelial keratopathy, keratitis, stromal edema, increased intraocular pressure, hypersensitivity reactions

No data reported

Refrigerate at 2°C to 8°C (36°F to 46°F); storage at room temperature may result in a solution altered pH which could result in ocular discomfort upon administration and/or decreased potency

Interferes with viral replication by incorporating into viral DNA in place of thymidine, inhibiting thymidylate synthetase resulting in the formation of defective proteins

Absorption: Ophthalmic instillation: Systemic absorption is negligible, while corneal penetration is adequate

Adults: Instill 1 drop into affected eye every 2 hours while awake, to a maximum of 9 drops/day, until re-epithelialization of corneal ulcer occurs; then use 1 drop every 4 hours for another 7 days; do not exceed 21 days of treatment; if improvement has not taken place in 7-14 days, consider another form of therapy

None reported

None reported

No information available to require special precautions

No effects or complications reported

For ophthalmic use only. Store in refrigerator; do not use discolored solution. Apply prescribed amount as often as directed. Wash hands before using and do not let tip of applicator touch eye or contaminate tip of applicator. Tilt head back and look upward. Gently pull down lower lid and put drop(s) in inner corner of eye. Close eye and roll eyeball in all directions. Do not blink for 1/2 minute. Apply gentle pressure to inner corner of eye for 30 seconds. Wipe away excess from skin around eye. Do not use any other eye preparation for at least 10 minutes. Do not touch tip of applicator to eye or contaminate tip of applicator. Do not share medication with anyone else. May cause sensitivity to bright light (dark glasses may help); temporary stinging or blurred vision may occur. Inform prescriber if you experience eye pain, redness, burning, watering, dryness, double vision, puffiness around eye, vision disturbances, or other adverse eye response; worsening of condition or lack of improvement within 7-14 days. Pregnancy/breast-feeding precautions: Inform prescriber if you are pregnant. Consult prescriber if breast-feeding.

Monitor ophthalmologic exam (test for corneal staining with fluorescein or rose bengal)

Solution, ophthalmic: 1% (7.5 mL)