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Pronunciation |
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(TRYE
en
teen) |
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U.S. Brand
Names |
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Syprine® |
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Generic
Available |
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No |
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Synonyms |
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Trientine Hydrochloride |
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Pharmacological Index |
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Chelating Agent |
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|
Use |
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Treatment of Wilson's disease in patients intolerant to
penicillamine |
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Pregnancy Risk
Factor |
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C |
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Contraindications |
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Rheumatoid arthritis, biliary cirrhosis, cystinuria, known hypersensitivity
to trientine |
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Warnings/Precautions |
|
May cause iron deficiency anemia; monitor closely; use with caution in
patients with reactive airway disease |
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Adverse
Reactions |
|
Percentage unknown: Malaise, iron deficiency, heartburn, epigastric pain,
anemia, tenderness, thickening and fissuring of skin, muscle cramps, systemic
lupus erythematosus (SLE), dystonia, muscular spasm, myasthenia
gravis |
|
|
Overdosage/Toxicology |
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Overdosage is unknown; a single 30 g ingestion resulted in no toxicity
Following GI decontamination, treatment is supportive |
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Drug
Interactions |
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Decreased effect with iron and possibly other mineral
supplements |
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Mechanism of
Action |
|
Trientine hydrochloride is an oral chelating agent structurally dissimilar
from penicillamine and other available chelating agents; an effective oral
chelator of copper used to induce adequate cupriuresis |
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|
Usual Dosage |
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Oral (administer on an empty stomach):
Adults: 750-1250 mg/day in divided doses 2-4 times/day; maximum dose: 2 g/day
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Dietary
Considerations |
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Should be administered 1 hour before or 2 hours after meals and at least 1
hour apart from any drug, food, or milk |
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Mental Health: Effects
on Mental Status |
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May cause drowsiness |
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|
Mental Health:
Effects on Psychiatric
Treatment |
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None reported |
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Patient
Information |
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Take 1 hour before or 2 hours after meals and at least 1 hour apart from any
drug, food, or milk; do not chew capsule, swallow whole followed by a full glass
of water; notify physician of any fever or skin changes; any skin exposed to the
contents of a capsule should be promptly washed with water |
|
|
Nursing
Implications |
|
Do not chew capsule, swallow whole followed by a full glass of water; notify
physician of any fever or skin changes; any skin exposed to the contents of a
capsule should be promptly washed with water |
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|
Dosage Forms |
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Capsule, as hydrochloride: 250 mg |
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References |
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Stavinoha MW and Soloway RD, "Current Therapy of Chronic Liver Disease,"
Drugs, 1990, 39(6):814-40.
Tankanow RM, "Pathophysiology and Treatment of Wilson's Disease," Clin
Pharm, 1991, 10(11):839-49.
Walshe JM,
"Treatment of Wilson's Disease With Trientine (Triethylene Tetramine) Dihydrochloride,"
Lancet, 1982, 1(8273):643-7. |
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