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| U.S. Brand Names |
| Colgate Total® Toothpaste |
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| Pharmacological Index |
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Antibacterial, Dental; Mineral, Oral; Mineral, Oral Topical |
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| Use |
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Anticavity, antigingivitis, antiplaque toothpaste |
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| Pregnancy Risk Factor |
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No data reported |
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| Warnings/Precautions |
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Antigingivitis and antiplaque effects have not been determined in children less than 6 years of age. If an amount greater than used for brushing is swallowed, seek professional assistance of contact a poison control center immediately |
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| Adverse Reactions |
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No data reported |
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| Mechanism of Action |
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Triclosan is an antibacterial agent which helps to prevent gingivitis with regular use. Fluoride promotes remineralization of decalcified enamel, inhibits the cariogenic microbial process in dental plaque, and increases tooth resistance to acid dissolution |
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| Usual Dosage |
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Brush teeth thoroughly after each meal or at least twice daily |
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| Dietary Considerations |
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No data reported |
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| Dental Health: Local Anesthetic/Vasoconstrictor Precautions |
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No information available to require special precautions |
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| Dental Health: Effects on Dental Treatment |
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No effects or complications reported |
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| Dosage Forms |
|
Toothpaste, in 4.2 oz (119g) tube (contains triclosan 0.30% and sodium fluoride 0.24%) |
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| References |
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Binney A, Addy M, Owens J, et al, "A Comparison of Triclosan and Stannous Fluoride Toothpastes for Inhibition of Plaque Growth," J Clin Periodontol, 1997, 24:166-70. Ellwood RP, Worthington HV, Blinkhorn AS, et al, "Effect of a Triclosan/Copolymer Dentifrice on the Incidence of Periodontal Attachment Loss in Adolescents," J Clin Periodontol, 1998, 25(5):363-7. Mandel ID, "The New Toothpastes," J Calif Dent Assoc, 1998, 26(3):186-90. Rosling B, Wannfors B, Volpe AR, et a, "The Use of a Triclosan/Copolymer Dentifrice May Retard the Progression of Periodontitis," J Clin Periodontol, 1997, 24:873-80. |
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