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Pronunciation |
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(toe
bra MYE sin & deks a METH a
sone) |
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U.S. Brand
Names |
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TobraDex®
Ophthalmic |
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Generic
Available |
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No |
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Synonyms |
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Dexamethasone and Tobramycin |
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Pharmacological Index |
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Antibiotic/Corticosteroid, Ophthalmic |
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Use |
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Treatment of external ocular infection caused by susceptible gram-negative
bacteria and steroid responsive inflammatory conditions of the palpebral and
bulbar conjunctiva, lid, cornea, and anterior segment of the
globe |
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Pregnancy Risk
Factor |
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B |
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Adverse
Reactions |
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1% to 10%:
Ocular: Lacrimation, itching, edema of eyelid, keratitis, increased
intraocular pressure, glaucoma, cataract formation |
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Drug
Interactions |
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Refer to individual monographs for Tobramycin and
Dexamethasone |
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Mechanism of
Action |
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Refer to individual monographs for Dexamethasone and
Tobramycin |
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Pharmacodynamics/Kinetics |
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Absorption: Absorbed into the aqueous humor
Time to peak serum concentration: 1-2 hours after instillation in the cornea
and aqueous humor |
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Usual Dosage |
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Children and Adults: Ophthalmic: Instill 1-2 drops of solution every 4 hours;
apply ointment 2-3 times/day; for severe infections apply ointment every 3-4
hours, or solution 2 drops every 30-60 minutes initially, then reduce to less
frequent intervals |
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Dental Health: Local
Anesthetic/Vasoconstrictor
Precautions |
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No information available to require special precautions |
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Dental Health:
Effects on Dental Treatment |
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No effects or complications reported |
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Patient
Information |
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Shake well before using, do not touch dropper to eye, apply light finger
pressure on lacrimal sac for 1 minute following instillation; notify physician
if condition fails to improve or worsens |
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Nursing
Implications |
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Shake well before using, do not touch dropper to eye, apply light finger
pressure on lacrimal sac for 1 minute following instillation; notify physician
if condition fails to improve or worsens |
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Dosage Forms |
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Ointment, ophthalmic: Tobramycin 0.3% and dexamethasone 0.1% (3.5 g)
Suspension, ophthalmic: Tobramycin 0.3% and dexamethasone 0.1% (2.5 mL, 5 mL)
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