No

Antifungal Agent, Vaginal

Local treatment of vulvovaginal candidiasis

C

Known hypersensitivity to tioconazole

Not effective when applied to the scalp; may interact with condoms and vaginal contraceptive diaphragms; avoid these products for 3 days following treatment

1% to 10%: Genitourinary: Vulvar/vaginal burning

<1%: Vulvar itching, soreness, edema, or discharge; polyuria

No data reported

A 1-substituted imidazole derivative with a broad antifungal spectrum against a wide variety of dermatophytes and yeasts, usually at a concentration less than or equal to 6.25 mg/L; has been demonstrated to be at least as active in vitro as other imidazole antifungals. In vitro, tioconazole has been demonstrated 2-8 times as potent as miconazole against common dermal pathogens including Trichophyton mentagrophytes, T. rubrum, T. erinacei, T. tonsurans, Microsporum canis, Microsporum gypseum, and Candida albicans. Both agents appear to be similarly effective against Epidermophyton floccosum.

Absorption: Intravaginal: Following application small amounts of drug are absorbed systemically (25%) within 2-8 hours; therapeutic levels persist for 3-5 days after single dose

Half-life: 21-24 hours

Elimination: Urine and feces in approximate equal amounts

Adults: Vaginal: Insert 1 applicatorful in vagina, just prior to bedtime, as a single dose; therapy may extend to 7 days

No information available to require special precautions

No effects or complications reported

Complete full course of therapy as directed. Insert vaginally as directed by prescriber or see package insert. Report persistent vaginal burning, itching, irritation, or discharge. Breast-feeding precautions: Consult prescriber if breast-feeding.

Insert high into vagina; contact physician if itching or burning continues

Cream, vaginal: 6.5% with applicator (4.6 g)