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Pronunciation |
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(thye
roe TROE
pin) |
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U.S. Brand
Names |
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Thytropar® |
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Generic
Available |
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No |
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Synonyms |
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Thyroid Stimulating Hormone; Thyrotropic Hormone; TSH |
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Pharmacological Index |
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Diagnostic Agent, Thyroid Function |
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Use |
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Diagnostic aid to differentiate thyroid failure; diagnosis of decreased
thyroid reserve, to differentiate between primary and secondary hypothyroidism
and between primary hypothyroidism and euthyroidism in patients receiving
thyroid replacement |
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Pregnancy Risk
Factor |
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C |
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Contraindications |
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Coronary thrombosis, untreated Addison's disease, hypersensitivity to
thyrotropin or any component |
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|
Warnings/Precautions |
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Use with caution in patients with angina pectoris or cardiac failure,
patients with hypopituitarism, adrenal cortical suppression as may be seen with
corticosteroid therapy; may cause thyroid hyperplasia |
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Adverse
Reactions |
|
<1%: Tachycardia, fever, headache, menstrual irregularities, nausea,
vomiting, increased bowel motility, anaphylaxis with repeated
administration |
|
|
Overdosage/Toxicology |
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Symptoms of overdose include weight loss, nervousness, sweating, tachycardia,
insomnia, heat intolerance, menstrual irregularities, headache, angina pectoris,
CHF
Acute massive overdose may require cardiac glycosides for CHF; fever should
be controlled with the help of acetaminophen; antiadrenergic agents,
particularly propranolol 1-3 mg I.V. every 6 hours or 80-160 mg/day, can be used
to treat increased sympathetic activity. |
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Drug
Interactions |
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No data reported |
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|
Stability |
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Refrigerate at 2°C to 8°C
(36°F to 46°F) after reconstitution;
use within 2 weeks |
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Mechanism of
Action |
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Stimulates formation and secretion of thyroid hormone, increases uptake of
iodine by thyroid gland |
|
|
Pharmacodynamics/Kinetics |
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Half-life: 35 minutes, dependent upon thyroid state
Elimination: Rapidly by the kidney in the urine |
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Usual Dosage |
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Adults: I.M., S.C.: 10 units/day for 1-3 days; follow by a radioiodine study
24 hours past last injection, no response in thyroid failure, substantial
response in pituitary failure |
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|
Dental Health: Local
Anesthetic/Vasoconstrictor
Precautions |
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No information available to require special precautions |
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Dental Health:
Effects on Dental Treatment |
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No effects or complications reported |
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Patient
Information |
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You will receive this medication for 3 days prior to the radiologic studies.
You may experience some nausea or vomiting. Report dizziness, faintness,
palpitations, or any respiratory difficulties. Pregnancy precautions:
Inform prescriber if you are or intend to be pregnant. |
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Dosage Forms |
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Injection: 10 units |
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