| Pronunciation |
 (THROM
bin, TOP i
kal) |
 |
| U.S. Brand Names |
| Thrombinar®; Thrombogen®; Thrombostat® |
|
| Generic Available |
|
No |
|
| Pharmacological Index |
|
Hemostatic Agent |
|
| Use |
|
Dental & Medical: Hemostasis whenever minor bleeding from capillaries and small venules is accessible |
|
| Pregnancy Risk Factor |
|
C |
|
| Contraindications |
|
Hypersensitivity to thrombin or any component |
|
| Warnings/Precautions |
|
Do not inject, for topical use only |
|
| Adverse Reactions |
|
1% to 10%: Miscellaneous: Allergic type reaction |
|
| Drug Interactions |
|
No data reported |
|
| Stability |
|
Refrigerate |
|
| Mechanism of Action |
|
Catalyzes the conversion of fibrinogen to fibrin |
|
| Usual Dosage |
|
Use 1000-2000 units/mL of solution where bleeding is profuse; apply powder directly to the site of bleeding or on oozing surfaces; use 100 units/mL for bleeding from skin or mucosal surfaces |
|
| Administration |
|
May be applied directly as a powder or as reconstituted solution; use sterile water or sodium chloride 0.9% to reconstituted powder to desired concentration; sponge surface free of blood prior to application, if possible |
|
| Dental Health: Local Anesthetic/Vasoconstrictor Precautions |
|
No information available to require special precautions |
|
| Dental Health: Effects on Dental Treatment |
|
No effects or complications reported |
|
| Patient Information |
|
External use only |
|
| Dosage Forms |
|
Powder: 1000 units, 5000 units, 10,000 units, 20,000 units, 50,000 units |
|
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