No

Antibacterial, Dental

Dental: Treatment of adult periodontitis; as an adjunct to scaling and root planing for the reduction of pocket depth and bleeding on probing in selected patients with adult periodontitis

Medical: No data reported

C

Known hypersensitivity to tetracyclines

Use of tetracyclines is not recommended during pregnancy because of interference with fetal bone and dental development

1% to 10%:

Miscellaneous: Discomfort from fiber placement

No data reported

Tetracycline is an antibiotic which inhibits growth of susceptible microorganisms. Tetracycline binds primarily to the 30S subunits of bacterial ribosomes, and appears to prevent access of aminoacyl tRNA to the acceptor site on the mRNA-ribosome complex. The fiber releases tetracycline into the periodontal site at a rate of 2 mcg/cm/hour.

The fiber releases tetracycline at a rate of 2 mcg/cm/hour

Tissue fluid concentrations:

Gingival fluid: ~1590 mcg/mL of tetracycline per site over 10 days

Plasma: During fiber treatment of up to 11 teeth, the tetracycline plasma concentration was below any detectable levels (<0.1 mcg/mL)

Oral: 500 mg of tetracycline produces a peak plasma level of 3-4 mcg/mL

Saliva: ~50.7 mcg/mL of tetracycline immediately after fiber treatment of 9 teeth

Children: Has not been established

Adults: Insert fiber to fill the periodontal pocket; each fiber contains 12.7 mg of tetracycline in 23 cm (9 inches) and provides continuous release of drug for 10 days; fibers are to be secured in pocket with cyanoacrylate adhesive and left in place for 10 days

No data reported

No information available to require special precautions

1% to 10% of patients experience gingival inflammation, pain in mouth, glossitis, candidiasis, staining of tongue

Fibers 23 cm (9") in length; 12.7 mg of tetracycline hydrochloride per fiber

Baer PN, "Actisite (Tetracycline Hydrochloride Periodontal Fiber): A Critique," Periodontal Clin Investig, 1994, 16(2):5-7.

Greenstein G, "Treating Periodontal Diseases With Tetracycline-Impregnanted Fibers: Data and Controversies," Compend Contin Educ Dent, 1995, 16(5)448-55.

Kerry G, "Tetracycline-Loaded Fibers as Adjunctive Treatment in Periodontal Disease," J Am Dent Assoc, 1994, 125(9):1199-203.

Michalowicz BS, Pihlstrom BL, Drisko CL, et al, "Evaluation of Periodontal Treatments Using Controlled-Release Tetracycline Fibers: Maintenance Response," J Periodontol, 1995, 66(8):708-15.

Mombelli A, Lehmann B, Tonetti M, et al, "Clinical Response to Local Delivery of Tetracycline in Relation to Overall and Local Periodontal Conditions," J Clin Periodontol, 1997, 24(7):470-77.

Vandekerckhove BN, Quirynen M, and van Steenberghe D, "The Use of Tetracycline-Containing Controlled-Release Fibers in the Treatment of Refractory Periodontitis," J Periodontol, 1997, 68(4):353-61.