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Pronunciation |
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(TET
a nus i MYUN GLOB yoo lin HYU
man) |
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U.S. Brand
Names |
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Hyper-Tet® |
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Generic
Available |
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No |
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Synonyms |
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TIG |
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Pharmacological Index |
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Immune Globulin |
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Use |
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Passive immunization against tetanus; tetanus immune globulin is preferred
over tetanus antitoxin for treatment of active tetanus; part of the management
of an unclean, wound in a person whose history of previous receipt of tetanus
toxoid is unknown or who has received less than three doses of tetanus toxoid;
elderly may require TIG more often than younger patients with tetanus infection
due to declining antibody titers with age |
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Pregnancy Risk
Factor |
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C |
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Contraindications |
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Hypersensitivity to tetanus immune globulin, thimerosal, or any immune
globulin product or component; patients with IgA deficiency; I.V.
administration |
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Warnings/Precautions |
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Have epinephrine 1:1000 available for anaphylactic reactions; do not
administer I.V. |
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Adverse
Reactions |
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>10%: Local: Pain, tenderness, erythema at injection site
1% to 10%:
Central nervous system: Fever (mild)
Dermatologic: Urticaria, angioedema
Neuromuscular & skeletal: Muscle stiffness
Miscellaneous: Anaphylaxis reaction
<1%: Sensitization to repeated injections |
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Drug
Interactions |
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Never administer tetanus toxoid and TIG in same syringe (toxoid will be
neutralized); toxoid may be given at a separate site; concomitant administration
with Td may decrease its immune response, especially in individuals with low
prevaccination antibody titers |
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Stability |
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Refrigerate |
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Mechanism of
Action |
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Passive immunity toward tetanus |
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Pharmacodynamics/Kinetics |
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Absorption: Well absorbed |
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Usual Dosage |
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I.M.:
Children: 4 units/kg; some recommend administering 250 units to small
children
Adults: 250 units
Treatment of tetanus:
Children: 500-3000 units; some should infiltrate locally around the wound
Adults: 3000-6000 units |
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Administration |
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Do not administer I.V.; I.M. use only |
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Dental Health: Local
Anesthetic/Vasoconstrictor
Precautions |
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No information available to require special precautions |
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Dental Health:
Effects on Dental Treatment |
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No effects or complications reported |
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Patient
Information |
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Be aware of adverse reactions |
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Dosage Forms |
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Injection: 250 units/mL |
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