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Pronunciation |
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(TET
a nus an tee TOKS
in) |
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Generic
Available |
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No |
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Synonyms |
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TAT |
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Pharmacological Index |
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Antitoxin |
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Use |
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Tetanus prophylaxis or treatment of active tetanus only when tetanus immune
globulin (TIG) is not available; tetanus immune globulin
(Hyper-Tet®) is the preferred tetanus immunoglobulin for
the treatment of active tetanus; may be given concomitantly with tetanus toxoid
adsorbed when immediate treatment is required, but active immunization is
desirable |
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Pregnancy Risk
Factor |
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D |
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Contraindications |
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Patients sensitive to equine-derived preparations |
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Warnings/Precautions |
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Tetanus antitoxin is not the same as tetanus immune globulin; sensitivity
testing should be conducted in all individuals regardless of clinical history;
have epinephrine 1:1000 available |
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Adverse
Reactions |
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greater than or equal to 10%: Skin eruptions, erythema, urticaria, local
pain, numbness, arthralgia, serum sickness may develop up to several weeks after
injection, anaphylaxis |
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Stability |
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Refrigerate, do not freeze |
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Mechanism of
Action |
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Provides passive immunization; solution of concentrated globulins containing
antitoxic antibodies obtained from horse serum after immunization against
tetanus toxin |
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Usual Dosage |
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Prophylaxis: I.M., S.C.:
Children <30 kg: 1500 units
Children and Adults greater than or equal to 30 kg: 3000-5000 units
Treatment: Children and Adults: Inject 10,000-40,000 units into wound;
administer 40,000-100,000 units |
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Nursing
Implications |
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All patients should have sensitivity testing prior to starting therapy with
tetanus antitoxin |
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Dosage Forms |
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Injection, equine: Not less than 400 units/mL (12.5 mL, 50
mL) |
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