No

Nonsteroidal Anti-Inflammatory Agent (NSAID)

Inhibition of intraoperative miosis

C

Previous hypersensitivity or intolerance to suprofen; epithelial herpes simplex keratitis; history of hypersensitivity reactions to aspirin or other nonsteroidal anti-inflammatory agents

Use with caution in patients sensitive to acetylsalicylic acid and other NSAIDs; some systemic absorption occurs; use with caution in patients with bleeding tendencies; perform ophthalmic evaluation for those who develop eye complaints during therapy (blurred vision, diminished vision, changes in color vision, retinal changes)

1% to 10%: Topical: Transient burning or stinging, redness, iritis

<1%: Chemosis, photophobia, discomfort, pain, punctate epithelial staining

Not usually a problem; if accidental oral ingestion, dilute with fluids

Decreased effect: When used concurrently with suprofen, acetylcholine chloride and carbachol may be ineffective

Inhibits prostaglandin synthesis, acts on the hypothalamus heat-regulating center to reduce fever, blocks prostaglandin synthetase action which prevents formation of the platelet-aggregating substance thromboxane A₂; decreases pain receptor sensitivity.

Protein binding: 99%

Metabolism: Occurs in the liver to one major inactive metabolite

Half-life, elimination: 2-4 hours

Time to peak serum concentration: ~1 hour

Elimination: <15% excreted unchanged in urine in 48 hours

Adults: On day of surgery, instill 2 drops in conjunctival sac at 3, 2, and 1 hour prior to surgery; or 2 drops in sac every 4 hours, while awake, the day preceding surgery

None reported

None reported

No information available to require special precautions

NSAID formulations are known to reversibly decrease platelet aggregation via mechanisms different than observed with aspirin. The dentist should be aware of the potential of abnormal coagulation. Caution should also be exercised in the use of NSAIDs in patients already on anticoagulant therapy with drugs such as warfarin (Coumadin®).

Avoid aspirin and aspirin-containing products while taking this medication; get instructions on administration of eye drops

In elderly, remove contact lenses before administering; assess ability to self-administer

Solution, ophthalmic: 1% (2.5 mL)