|
Pronunciation |
|
(sul
fa meth OKS a zole & fen az
oh PEER i deen) |
|
|
Generic
Available |
|
Yes |
|
|
Synonyms |
|
Phenazopyridine and Sulfamethoxazole |
|
|
Pharmacological Index |
|
Antibiotic, Sulfonamide Derivative |
|
|
Use |
|
Treatment of urinary tract infections complicated with
pain |
|
|
Pregnancy Risk
Factor |
|
B/D (at term) |
|
|
Contraindications |
|
Porphyria; hypersensitivity to any sulfa drug or any
component |
|
|
Adverse
Reactions |
|
Central nervous system: Confusion, depression, hallucinations, ataxia,
seizures, fever, kernicterus in neonates
Dermatologic: Rash, erythema multiforme, Stevens-Johnson syndrome, epidermal
necrolysis
Gastrointestinal: Nausea, vomiting, glossitis, stomatitis, diarrhea,
pseudomembranous colitis
Hematologic: Thrombocytopenia, megaloblastic anemia, granulocytopenia,
aplastic anemia, hemolysis (with G-6-PD deficiency)
Hepatic: Serum sickness, hepatitis
Renal & genitourinary: Interstitial nephritis |
|
|
Drug
Interactions |
|
Warfarin, methotrexate |
|
|
Usual Dosage |
|
Oral: 4 tablets to start, then 2 tablets twice daily for up to 2 days, then
switch to sulfamethoxazole only |
|
|
Dietary
Considerations |
|
Should be administered 1 hour before or 2 hours after a meal on an empty
stomach |
|
|
Mental Health: Effects
on Mental Status |
|
May cause confusion, depression, and hallucinations; sulfonamides reported to
cause restlessness, irritability, euphoria, disorientation, panic, and
delusions |
|
|
Mental Health:
Effects on Psychiatric
Treatment |
|
Photosensitivity is common; use caution with concurrent psychotropics; may
cause leukopenia; caution with clozapine and carbamazepine |
|
|
Dental Health: Local
Anesthetic/Vasoconstrictor
Precautions |
|
No information available to require special precautions |
|
|
Dental Health:
Effects on Dental Treatment |
|
No effects or complications reported |
|
|
Patient
Information |
|
See individual agents. Pregnancy/breast-feeding precautions: Inform
prescriber if you are or intend to get pregnant. Consult prescriber if
breast-feeding. |
|
|
Nursing
Implications |
|
Urine may be discolored orange-red; when possible, obtain specimens for
culture and sensitivity before the first dose; review allergy
history |
|
|
Dosage Forms |
|
Tablet: Sulfamethoxazole 500 mg and phenazopyridine 100
mg |
|
Copyright © 1978-2000 Lexi-Comp Inc. All Rights Reserved
|