|
| Pronunciation |
 (sul
fa DYE a zeen sul fa METH a zeen
& sul fa MER a zeen) |
 |
| Generic Available |
|
No |
|
| Synonyms |
| Multiple Sulfonamides; Trisulfapyrimidines |
|
| Pharmacological Index |
|
Antibiotic, Sulfonamide Derivative; Antibiotic, Topical |
|
| Use |
|
Treatment of toxoplasmosis and other susceptible organisms, however, other agents are preferred |
|
| Pregnancy Risk Factor |
|
B (D at term) |
|
| Contraindications |
|
Porphyria, known hypersensitivity to any sulfa drug or any component |
|
| Mechanism of Action |
|
Interferes with microbial folic acid synthesis and growth via inhibition of para-aminobenzoic acid metabolism |
|
| Pharmacodynamics/Kinetics |
|
Metabolism: By acetylation Elimination: Excreted in urine via glomerular filtration |
|
| Usual Dosage |
|
Adults: Oral: 2-4 g to start, then 2-4 g/day in 3-6 divided doses |
|
| Dietary Considerations |
|
Should be administered 1 hour before or 2 hours after a meal on an empty stomach |
|
| Test Interactions |
|
Increases cholesterol (S), protein, uric acid (S) |
|
| Dental Health: Local Anesthetic/Vasoconstrictor Precautions |
|
No information available to require special precautions |
|
| Dental Health: Effects on Dental Treatment |
|
No effects or complications reported |
|
| Patient Information |
|
Drink plenty of fluids |
|
| Nursing Implications |
|
Drink plenty of fluids |
|
| Dosage Forms |
|
Tablet: Sulfadiazine 167 mg, sulfamethazine 167 mg, and sulfamerazine 167 mg |
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