|
| Pronunciation |
 (sul
fa BENZ a mide, sul fa SEE ta
mide & sul fa THYE a zole) |
 |
| U.S. Brand Names |
| Femguard®; Gyne-Sulf®; Sulfa-Gyn®; Sulfa-Trip®; Sultrin™; Trysul®; V.V.S.® |
|
| Generic Available |
|
Yes |
|
| Synonyms |
| Triple Sulfa |
|
| Pharmacological Index |
|
Antibiotic, Vaginal |
|
| Use |
|
Treatment of Haemophilus vaginalis vaginitis |
|
| Pregnancy Risk Factor |
|
C (avoid if near term) |
|
| Contraindications |
|
Hypersensitivity to sulfabenzamide, sulfacetamide, sulfathiazole or any component, renal dysfunction |
|
| Warnings/Precautions |
|
Associated with Stevens-Johnson syndrome; if local irritation or systemic toxicity develops, discontinue therapy |
|
| Adverse Reactions |
|
>10%: Local: Irritation, pruritus, urticaria <1%: Allergic reactions, Stevens-Johnson syndrome |
|
| Drug Interactions |
|
No data reported |
|
| Mechanism of Action |
|
Interferes with microbial folic acid synthesis and growth via inhibition of para-aminobenzoic acid metabolism |
|
| Pharmacodynamics/Kinetics |
|
Absorption: Absorption from the vagina is variable and unreliable Metabolism: Primarily by acetylation Elimination: By glomerular filtration into urine |
|
| Usual Dosage |
|
Adults: Tablet: Insert one intravaginally twice daily for 10 days |
|
| Dental Health: Local Anesthetic/Vasoconstrictor Precautions |
|
No information available to require special precautions |
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| Dental Health: Effects on Dental Treatment |
|
No effects or complications reported |
|
| Patient Information |
|
This medication is to be inserted into vagina; do not ingest tablets. Complete full course of therapy. Wash hands before inserting applicator gently into vagina and releasing cream or tablet. Wash hands and applicator with soap and water following each application. Discontinue and notify prescriber immediately if burning, irritation, or signs of allergic reaction occur. Pregnancy/breast-feeding precautions: Inform prescriber if you are pregnant before use. Consult prescriber if breast-feeding. |
|
| Nursing Implications |
|
Complete full course of therapy; notify physician if burning, irritation, or signs of a systemic allergic reaction occur |
|
| Dosage Forms |
|
Cream, vaginal: Sulfabenzamide 3.7%, sulfacetamide 2.86%, and sulfathiazole 3.42% (78 g with applicator, 90 g, 120 g) Tablet, vaginal: Sulfabenzamide 184 mg, sulfacetamide 143.75 mg, and sulfathiazole 172.5 mg (20 tablets/box with vaginal applicator) |
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